Difference between revisions of "Folded-foldamer pushing approach"
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| − | This approach competes against [[self-assembly]] | + | This page is about the possible approach of <br> |
| + | pushing (or pulling if possible) small already self-assembled structures around on a surface <br> | ||
| + | in order to assemble them via [[SPM]] ([[Top down positional assembly]]) to bigger structures. <br> | ||
| + | Small means: All the input parts have undergone just the first level of [[hierarchical self-assembly]]. <br> | ||
| + | Structures hight e.g. include stiff & sturdy designed [[de-novo proteins]]. | ||
| + | |||
| + | '''This approach competes against [[self-assembly]].''' <br> | ||
| + | And this is a symptom of the [[Positional assembly redundancy blockade]]. | ||
| + | |||
| + | == PROs & CONs == | ||
| + | |||
| + | '''Advantages:''' <br> | ||
| + | Basically evading development difficulties of selfassembly. E.g.no need to develop: <br> | ||
| + | – large orthogonal sets of complementary surfaces or <br> | ||
| + | – [[iterative selfassembly]] <br> | ||
| + | – [[squigglesembly]], [[circumsembly]], ... | ||
'''Difficulties for pushing folded proteins around by SPM may include:''' <br> | '''Difficulties for pushing folded proteins around by SPM may include:''' <br> | ||
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– only perhaps: crushing the specimen issues | – only perhaps: crushing the specimen issues | ||
| − | '''Inferiorities to self-assembly when working include:''' <br> | + | '''Inferiorities relative to self-assembly when working include:''' <br> |
– only one product (or a few with additional difficulties) rather than several orders of magnitude simultaneously <br> | – only one product (or a few with additional difficulties) rather than several orders of magnitude simultaneously <br> | ||
– assembly of each new product takes long | – assembly of each new product takes long | ||
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== Related == | == Related == | ||
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* [[Incremental path]] | * [[Incremental path]] | ||
* [[Top down positional assembly]] | * [[Top down positional assembly]] | ||
| + | * [[self-assembly]], [[positional assembly]] | ||
| + | * [[Direct path]] | ||
Revision as of 13:13, 17 September 2022
This page is about the possible approach of
pushing (or pulling if possible) small already self-assembled structures around on a surface
in order to assemble them via SPM (Top down positional assembly) to bigger structures.
Small means: All the input parts have undergone just the first level of hierarchical self-assembly.
Structures hight e.g. include stiff & sturdy designed de-novo proteins.
This approach competes against self-assembly.
And this is a symptom of the Positional assembly redundancy blockade.
PROs & CONs
Advantages:
Basically evading development difficulties of selfassembly. E.g.no need to develop:
– large orthogonal sets of complementary surfaces or
– iterative selfassembly
– squigglesembly, circumsembly, ...
Difficulties for pushing folded proteins around by SPM may include:
– tip bluntness at the larger scale of softer proteins
– SPM control for larger vertical motions being very limited
– only perhaps: crushing the specimen issues
Inferiorities relative to self-assembly when working include:
– only one product (or a few with additional difficulties) rather than several orders of magnitude simultaneously
– assembly of each new product takes long
