Difference between revisions of "Circumsembly"
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| + | [[File:Circumsembly.png|600px|thumb|right|A semi-conceptual illustration visualizing fault tolerance in selfassembly | ||
| + | (at first and second assembly level) enabled by provision of parallel pathways for | ||
| + | the completion of still missing areas of self-assembly. – 3D voxel block [[structural DNA nanotechnology]] used as inspiring example. ]] | ||
| − | + | '''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br> | |
| + | different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br> | ||
| + | if up to (n-1) paths between A & B are blocked by irreversible assembly errors, self-assembly can still proceed from A all the way to B.<br> | ||
| + | In practice much less than (n-1) paths should ever be blocked and the wole product assembled. | ||
| + | Minus the few irreversible assembly errors which can be tolerated in a good design.<br> | ||
| + | {{wikitodo|add a sketch}} | ||
| + | |||
| + | (Choice of name: "circum" from circumventing assembly errors.) | ||
| + | |||
| + | == Relation to yield in the synthesis of chain molecules == | ||
| + | |||
| + | artificial synthesis of chain molecules by iterative addition of monomers to the reactive end <br> | ||
suffers from exponential/geometric drop-off in yield.<br> | suffers from exponential/geometric drop-off in yield.<br> | ||
With every added monomer a probability smaller one of failure is multiplied. <br> | With every added monomer a probability smaller one of failure is multiplied. <br> | ||
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But a stiff rod made from several parallel sub-strands can circumvent irreversible errors. | But a stiff rod made from several parallel sub-strands can circumvent irreversible errors. | ||
| − | == Prerequisites == | + | == Prerequisites for circumsembly == |
* selfassembly at multiple spots simultaneously | * selfassembly at multiple spots simultaneously | ||
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* sufficient stiffness of selfassemblies such that the same spot can be reached via multiple (at least two) pathways | * sufficient stiffness of selfassemblies such that the same spot can be reached via multiple (at least two) pathways | ||
| − | == Benefits == | + | == Benefits of circumsembly == |
* A much reduced dropoff in yield of product. <br>Especially for 2d and 3D structures where the number of paths for circumvention grows quadratically/cubically respectively. | * A much reduced dropoff in yield of product. <br>Especially for 2d and 3D structures where the number of paths for circumvention grows quadratically/cubically respectively. | ||
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This is likely easy for n=2 analytically. <br> | This is likely easy for n=2 analytically. <br> | ||
For bigger n this might be easiest answered with a simulation.<br> | For bigger n this might be easiest answered with a simulation.<br> | ||
| + | ---- | ||
| + | Multiple paths to the same point is larger than zero stiffness per path <br> | ||
| + | can contribute to overall shape based structural stiffness. <br> | ||
| + | One may hit the limits of [[persistence length]] later. | ||
== Related == | == Related == | ||
| − | * [[ | + | * [[termination control]] |
| + | * [[squigglesembly]] | ||
* [[de-novo proteins]] | * [[de-novo proteins]] | ||
| + | * [[steric traps]] | ||
| + | ---- | ||
| + | * [[Persistence length]] | ||
Latest revision as of 21:23, 18 November 2024
Circumsembly (or redundant access self-assembly) is selfassembly where
different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that
if up to (n-1) paths between A & B are blocked by irreversible assembly errors, self-assembly can still proceed from A all the way to B.
In practice much less than (n-1) paths should ever be blocked and the wole product assembled.
Minus the few irreversible assembly errors which can be tolerated in a good design.
(wiki-TODO: add a sketch)
(Choice of name: "circum" from circumventing assembly errors.)
Contents
[hide]Relation to yield in the synthesis of chain molecules
artificial synthesis of chain molecules by iterative addition of monomers to the reactive end
suffers from exponential/geometric drop-off in yield.
With every added monomer a probability smaller one of failure is multiplied.
An artificial selfassembled rod of de-novo proteins can suffer the same.
But a stiff rod made from several parallel sub-strands can circumvent irreversible errors.
Prerequisites for circumsembly
- selfassembly at multiple spots simultaneously
- sideward assembly crossing sub-strands is possible
- sufficient stiffness of selfassemblies such that the same spot can be reached via multiple (at least two) pathways
Benefits of circumsembly
- A much reduced dropoff in yield of product.
Especially for 2d and 3D structures where the number of paths for circumvention grows quadratically/cubically respectively.
The math for how the drop-off in yield is reduced exactly in not entirely nontrivial.
(wiki-TODO: check out the math more closely)
Minimal problem:
- Given A rod of n parallel rows of 2D-squares starting out empty adding to the right only.
- Successive addition at the growth front – this needs to accounting for sideward additions – nontrivial
- What is the average blocknumber till all paths are blocked
This is likely easy for n=2 analytically.
For bigger n this might be easiest answered with a simulation.
Multiple paths to the same point is larger than zero stiffness per path
can contribute to overall shape based structural stiffness.
One may hit the limits of persistence length later.
