Difference between revisions of "Foldamer R&D"
From apm
(→Related: added link to yet unwritten page Creating Reached milestones in foldamer R&D) |
(→External links: added link to a presentation of Christian Schafmeister + some discussion of that) |
||
| Line 20: | Line 20: | ||
* Wikipedia: [https://en.wikipedia.org/wiki/De_novo_protein_structure_prediction De_novo_protein_structure_prediction] | * Wikipedia: [https://en.wikipedia.org/wiki/De_novo_protein_structure_prediction De_novo_protein_structure_prediction] | ||
* Wikipedia: [https://en.wikipedia.org/wiki/Peptidomimetic Peptidomimetic][https://en.wikipedia.org/wiki/Peptoid Peptoid][https://en.wikipedia.org/wiki/Beta-peptide Beta-peptide] | * Wikipedia: [https://en.wikipedia.org/wiki/Peptidomimetic Peptidomimetic][https://en.wikipedia.org/wiki/Peptoid Peptoid][https://en.wikipedia.org/wiki/Beta-peptide Beta-peptide] | ||
| + | |||
| + | '''Video:''' | ||
| + | "Clasp: Common Lisp using LLVM and C++ for Molecular Metaprogramming" [https://www.youtube.com/watch?v=8X69_42Mj-g]<br> | ||
| + | Published on Jun 15, 2015 – Google Tech Talk – June 9, 2015 – Presented by Christian Schafmeister. | ||
| + | |||
| + | This video also brings up topics like: | ||
| + | * The importance of [[stiffness]] – double linked backbones prevent rotations making resulting structures much easier to desing and more predictable | ||
| + | * Iterative design of early forms of [[Kaehler bracket]]s <br>optimization of a stiff backbone to get functional groups as close as possible to a fixed predefined configuration (that may have been stolen from a natural protein) | ||
| + | * [[General software issues]] – programming language limitations, the dreaded interface problem, <br>"deforresting" unnecessary computer algebra reevaluations (a problem also showing up in volumetric 3D modelling aka distance field based [[3D modelling]]; [[Design levels]]),<br> the need for derivation towers (scalar,vector,tensor) (automatic derivation - links to Conal Elliotts work) | ||
| + | * The waste problem with POPs (persistent organic pollutants) -- See: [[Recycling]] | ||
| + | * The lignin pileup in the [https://en.wikipedia.org/wiki/Carboniferous Carboniferous] epoch of earths history. | ||
Revision as of 19:47, 14 August 2017
- structural DNA nanotechnology
- de-novo protein engineering
- peptidomimetics like peptoids (& beta-peptides)
- spiroligomers
Related
- Incremental path
- Reached milestones in foldamer R&D
- Self folding
- covalent cross interlinking (increasing stiffness)
- POPs (persistant organic pollutants) -- See: "Soil pollutants"
- Microfluidics
External links
- Wikipedia: Foldamer
- Wikipedia: De_novo_protein_structure_prediction
- Wikipedia: PeptidomimeticPeptoidBeta-peptide
Video:
"Clasp: Common Lisp using LLVM and C++ for Molecular Metaprogramming" [1]
Published on Jun 15, 2015 – Google Tech Talk – June 9, 2015 – Presented by Christian Schafmeister.
This video also brings up topics like:
- The importance of stiffness – double linked backbones prevent rotations making resulting structures much easier to desing and more predictable
- Iterative design of early forms of Kaehler brackets
optimization of a stiff backbone to get functional groups as close as possible to a fixed predefined configuration (that may have been stolen from a natural protein) - General software issues – programming language limitations, the dreaded interface problem,
"deforresting" unnecessary computer algebra reevaluations (a problem also showing up in volumetric 3D modelling aka distance field based 3D modelling; Design levels),
the need for derivation towers (scalar,vector,tensor) (automatic derivation - links to Conal Elliotts work) - The waste problem with POPs (persistent organic pollutants) -- See: Recycling
- The lignin pileup in the Carboniferous epoch of earths history.
