Selfassembly level
From apm
Selfassembly levels are the states between the steps taken in hierarchical selfassembly.
This is in analogy to assembly levels being the sates between the steps taken in convergent assembly.
- While selfassembly levels are for self assembly
- assembly levels are to positional assembly
Contents
Examples
SDN
Second assembly level selfassembly has already been demonstrated with structural DNA nanotechnology.
- First assembly level used base-pair complementary of highly flexible DNA oligonucleotide "bricks"
- Second assembly level used salt concentration to assemble big pre-assembled somewhat rigid blocks
This can be considered a major milestone reached.
SPN
As of mid 2022 structural de-novo protein nanotechnology seems still far from demonstrating
- second assembly level of selfassembly has been shown in the form of de-novo desing of shape complementary interfaces that worked experimentally (self folding being the first self-assembly step) - but termination control is still lacking.
- self finding is still on it's fist assembly level.
- The self folding of de-novo proteins on the first selfassembly level is much more limited in control over shapes compared to the first self finding in the first selfassembly level of SDN
Delineation
- First assembling two dimers and then assembling them to a tetramer (elsewhere). Is minimal but qualifies as hierarchical.
- First assembling a dimers and then adding a monomer to form a dimer (or vie versa) is rather just Iterative selfassembly.
