Structural DNA nanotechnology

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  • 2D DNA origami
  • extended 2D lattice crystals
  • 3D DNA cages
  • 3D DNA blocks made from staple Bricks as voxels
  • hierarchical shape assembly of blocks controlled by salt concentration
  • micro sized periodic 3D structures
  • structures with elastic links that act as rotation allowing hinges actuated by single strand DNA as entropic spring
  • more complex linkage structures including an sliding element
  • operation in non water solvents

DNA frameworks

DNA bricks


When one watches the simulation of the self assembly process of DNA bricks [TODO add link] one is led to doubt the stiffness of the product. The DNA double helix can create siff polymeres if the used doublehelix segments are kept in the length range from one to three turns. Mentioned here [1] under the section "DNA as Construction Material" and referenced here [1] (unchecked). Is there quantitative information about the stiffness of whole DNA bricks (to investigate)?

External links

Harvard's Wyss Institute:






  1. Hagerman, P.J. (1988), Flexibility of DNA, Ann. Rev. Biophys. & Biophys. Chem. 17, 265-286.