Foldamer R&D
From apm
Revision as of 17:03, 15 August 2017 by Apm (Talk | contribs) (→External links: elaborated by adding: "indestructibility" of spiroligomers)
- structural DNA nanotechnology
- de-novo protein engineering
- peptidomimetics like peptoids (& beta-peptides)
- spiroligomers
Related
- Incremental path
- Reached milestones in foldamer R&D
- Self folding
- covalent cross interlinking (increasing stiffness)
- POPs (persistant organic pollutants) -- See: "Soil pollutants"
- Microfluidics
External links
- Wikipedia: Foldamer
- Wikipedia: De_novo_protein_structure_prediction
- Wikipedia: PeptidomimeticPeptoidBeta-peptide
Video:
"Clasp: Common Lisp using LLVM and C++ for Molecular Metaprogramming" [1]
Published on Jun 15, 2015 – Google Tech Talk – June 9, 2015 – Presented by Christian Schafmeister.
This video also brings up topics like:
- The importance of stiffness – double linked backbones prevent rotations making resulting structures much easier to desing and more predictable
- Iterative design of early forms of Kaehler brackets
optimization of a stiff backbone to get functional groups as close as possible to a fixed predefined configuration (that may have been stolen from a natural protein) - General software issues – programming language limitations, the dreaded interface problem,
"deforresting" unnecessary computer algebra reevaluations (a problem also showing up in volumetric 3D modelling aka distance field based 3D modelling; Design levels),
the need for derivation towers (scalar,vector,tensor) (automatic derivation - links to Conal Elliotts work) - Going deep down the rabbit-hole to reach a far term target (in an highly non-obvious way for outsiders).
Sidenote: That's exactly where natural evolution has severe limitations. - Invention (and market introduction) of covalent protein crosslinking technology
- Bootstrapping of the synthesis of the fundamental spiroligomer building blocks
- The "indestructibility" of spiroligomers raise the issue of the waste problem with POPs (persistent organic pollutants) -- See: Recycling
- The lignin pileup in the Carboniferous epoch of earths history.
- The talk doesn't look beyond towards gemstone based systems as far term goal. Partially brownian technology path?
