Difference between revisions of "Structural DNA nanotechnology"

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[[File:3D-blocks-from-DNA-bricks-concept.jpeg|600px|thumb|right|'''Especially impressive branch of structural DNA nanotechnology:''' 3D blocks/parts made from DNA bricks (bricks = short floppy DNA snippets aka oglionucleotides, not the whole blocks) This is conceptual but '''they have been experimentally made with great success'''. – Picture is Figure1 from the paper "Three-Dimensional Structures Self-Assembled from DNA Bricks" by Yonggang Ke,Luvena L. Ong, William M. Shih, Peng Yin]]
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* 2D DNA origami
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* extended 2D lattice crystals
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* 3D DNA cages
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* 3D DNA blocks made from staple Bricks as voxels
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* hierarchical shape assembly of blocks controlled by salt concentration
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* micro sized periodic 3D structures
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* structures with elastic links that act as rotation allowing hinges actuated by single strand DNA as entropic spring
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* more complex linkage structures including an sliding element
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* operation in non water solvents
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== DNA frameworks ==
 
== DNA frameworks ==
  
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Mentioned here [http://www.foresight.org/Conferences/MNT05/Papers/Seeman/index.html] under the section "DNA as Construction Material" and referenced here <ref>Hagerman, P.J. (1988), Flexibility of DNA, Ann. Rev. Biophys. & Biophys. Chem. 17, 265-286.</ref> (unchecked).
 
Mentioned here [http://www.foresight.org/Conferences/MNT05/Papers/Seeman/index.html] under the section "DNA as Construction Material" and referenced here <ref>Hagerman, P.J. (1988), Flexibility of DNA, Ann. Rev. Biophys. & Biophys. Chem. 17, 265-286.</ref> (unchecked).
 
Is there quantitative information about the stiffness of whole DNA bricks ('''to investigate''')?
 
Is there quantitative information about the stiffness of whole DNA bricks ('''to investigate''')?
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== External links ==
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Harvard's Wyss Institute:
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* [http://wyss.harvard.edu/viewpressrelease/173/crystallizing-the-dna-nanotechnology-dream large DNA crystals with precisely prescribed depths and complex 3D features] (paper ...)
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* [http://wyss.harvard.edu/viewpressrelease/101/researchers-create-versatile-3d-nanostructures-using-dna-bricks 3D DNA structures using DNA "Bricks"]
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* [http://wyss.harvard.edu/viewpressrelease/84/wyss-institute-develops-new-nanodevice-manufacturing-strategy-using-selfassembling-dna-building-blocks- DNA origami]
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* [http://wyss.harvard.edu/viewpressrelease/4 Scientists create custom three-dimensional structures with "DNA origami"]
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Other:
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* [http://kuchem.kyoto-u.ac.jp/chembio/research_e.html Kyoto University DNA Nanotechnology Group]
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* Paper on very large blocks: <br>[https://www.researchgate.net/publication/321637603_Programmable_self-assembly_of_three-dimensional_nanostructures_from_10000_unique_components Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components]<br> News coverage: [https://phys.org/news/2017-12-dna-bricks-enable-self-assembly-d.html phys.org on DECEMBER 21, 2017]
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Wikipedia:
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* [http://en.wikipedia.org/wiki/DNA_origami DNA origami]
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* [http://en.wikipedia.org/wiki/DNA_nanotechnology DNA nanotechnology]
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* [https://en.wikipedia.org/wiki/Oligonucleotide_synthesis Oligonucleotide synthesis]
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* [https://en.wikipedia.org/wiki/DNA_synthesis DNA synthesis]
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* [https://en.wikipedia.org/wiki/Carlson_curve Carlson curve]
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=== Videos ===
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* [https://www.youtube.com/watch?v=Trg2__Lgnc0 Ten years of DNA origami] (2016-03-18)
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* Short introduction video series to structural DNA nanotechnology by William Shih (Harvard) 2014-04 <br> [https://www.youtube.com/watch?v=Ek-FDPymyyg (Part 1: Nanofabrication via DNA Origami)] [https://www.youtube.com/watch?v=noWkRxKYBhU (Part 2: Nanofabrication via DNA Single Stranded Bricks )] [https://www.youtube.com/watch?v=5cmg1oa4-fg (Part 3: DNA-Nanostructure Tools)]
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* Youtube TEDMED: [https://www.youtube.com/watch?v=-5KLTonB3Pg early medical applications] still more on the side of the [[brownian technology path]]
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== Related ==
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* [[De-novo protein engineering]] – Compared to SDN it is [[stiffness|stiffer]] (good) but has less [[termination control]] (bad).
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* [[Steric traps]]
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* '''[[Hierarchical selfassembly]]'''
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* [[Algorithmic selfassembly]]
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* [[Stiffness]] – SDN lacks it quite a bit, so much in fact that <br>it only features [[topological atomic precision]] not [[positional atomic precision]]
  
 
== References ==
 
== References ==

Latest revision as of 13:17, 10 March 2024

This article is a stub. It needs to be expanded.
(wiki-TODO: add illustrative image)
Especially impressive branch of structural DNA nanotechnology: 3D blocks/parts made from DNA bricks (bricks = short floppy DNA snippets aka oglionucleotides, not the whole blocks) This is conceptual but they have been experimentally made with great success. – Picture is Figure1 from the paper "Three-Dimensional Structures Self-Assembled from DNA Bricks" by Yonggang Ke,Luvena L. Ong, William M. Shih, Peng Yin
  • 2D DNA origami
  • extended 2D lattice crystals
  • 3D DNA cages
  • 3D DNA blocks made from staple Bricks as voxels
  • hierarchical shape assembly of blocks controlled by salt concentration
  • micro sized periodic 3D structures
  • structures with elastic links that act as rotation allowing hinges actuated by single strand DNA as entropic spring
  • more complex linkage structures including an sliding element
  • operation in non water solvents

DNA frameworks

DNA bricks

[...]

When one watches the simulation of the self assembly process of DNA bricks [TODO add link] one is led to doubt the stiffness of the product. The DNA double helix can create siff polymeres if the used doublehelix segments are kept in the length range from one to three turns. Mentioned here [1] under the section "DNA as Construction Material" and referenced here [1] (unchecked). Is there quantitative information about the stiffness of whole DNA bricks (to investigate)?

External links

Harvard's Wyss Institute:

Other:

Wikipedia:

Videos

Related

References

  1. ↑ Hagerman, P.J. (1988), Flexibility of DNA, Ann. Rev. Biophys. & Biophys. Chem. 17, 265-286.
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