Difference between revisions of "Reached milestones in foldamer R&D"
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Revision as of 22:20, 22 August 2018
(wiki-TODO: add technology dependency diagram) (wiki-TODO: reference all the associated papers)
One can identify:
- progress in control of self assembly
- progress in means of actuation of the self assembled structures
Contents
Classified by foldamer type
DNA as building material
Highly relevant:
- ending reliance on viral DNA => fully abiotic process
- proof of atomic precision in DNA brick structures (via cryo-TEM-tomography)
- abstraction over low base part symmetry (orthorhombic and hexagonal - slight twist deformation though)
- introduction of highly localized compliance (aka hinges) and sliding rails
- two stage hierarchical self assembly (reversible second stage via stiff shape complementarity & salt concentration)
- demonstration of subatomic positional precision (via a hinge mechanism)
- multi micron scale atomically precise pegboard structures
- demonstration of fast electrostatic actuation of structural DNA assemblies
- ....
Maybe less relevant:
- DNA walkers (unidirectional & bidirectional) -- (TODO: link related online learning game)
- spacial digital counting (still crude) -- (TODO: link related talk video)
- stiff DNA triangle cages (note: deltohedrons are stiff polyhedrons)
- DNA tensegrity
de-novo proteins
- high symmetry de-novo protein sheets
- ...
Spiroligomers
- ... (TODO: investigate conducted research)
Makroscale base technologies
- DNA oglionucleotide synthesis
- Microfluidics (?)
