Difference between revisions of "Reached milestones in foldamer R&D"

Revision as of 05:54, 26 August 2018

(wiki-TODO: add technology dependency diagram) (wiki-TODO: reference all the associated papers)

One can identify:

• progress in control of self assembly
• progress in means of actuation of the self assembled structures

Classified by foldamer type

DNA as building material

Highly relevant:

• ending reliance on viral DNA => fully abiotic process
• proof of atomic precision in DNA brick structures (via cryo-TEM-tomography)
• abstraction over low base part symmetry (orthorhombic and hexagonal - slight twist deformation though)
• introduction of highly localized compliance (aka hinges) and sliding rails
• two stage hierarchical self assembly (reversible second stage via stiff shape complementarity & salt concentration)
• demonstration of subatomic positional precision (via a hinge mechanism)
• multi micron scale atomically precise pegboard structures
• demonstration of fast electrostatic actuation of structural DNA assemblies
• ....

Maybe less relevant:

• DNA walkers (unidirectional & bidirectional) -- (wiki-TODO: link related online learning game)
• spacial digital counting (still crude) -- (wiki-TODO: link related talk video)
• stiff DNA triangle cages (note: deltahedrons are stiff polyhedrons)
• DNA tensegrity

de-novo proteins

• high symmetry de-novo protein sheets
• ...

Spiroligomers

• ... (TODO: investigate conducted research)

Makroscale base technologies

• DNA oglionucleotide synthesis
• Microfluidics (?)

Related

• Foldamer R&D
• pending / outstanding milestone Mechanical demultiplexing