Difference between revisions of "Hierarchical selfassembly"
(shifting sections and adding demonstrations overview (with note on termination control)) |
(== Hierarchical selfassembly of 3D structural DNA nanotechnology (3D-SDN) == and notes on voxels) |
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* [[positional assembly]] (See: [[hierarchical positional assembly]]). | * [[positional assembly]] (See: [[hierarchical positional assembly]]). | ||
| − | + | = Experimental demonstrations = | |
As of time of last review (2024-03) hierarchical selfassembly has been … | As of time of last review (2024-03) hierarchical selfassembly has been … | ||
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Rotation symmetry is an infinite symmetry (just like translation symmetry in a crystal) just that it covers over itself. | Rotation symmetry is an infinite symmetry (just like translation symmetry in a crystal) just that it covers over itself. | ||
| − | + | == Hierarchical selfassembly of 3D [[structural DNA nanotechnology]] (3D-SDN) == | |
| − | [[File:Finite Assembly of Three‐Dimensional DNA.jpg|800px|thumb|right|'''First level of self-assembly''' is self folding of the staples strands (short DNA oligomers) to the hexagonal building blocks. Not shown. <br>'''Second level of self-assembly''' is self finding of the hexagonal building blocks. Shown. <br>Here this goes one step further in attempting to make a sandard set of blocks for the second assembly level such that arbitrary larger structures can be built quickly and easily. Custom blocks may be more versatile but are one off solutions for specific desireed geometeries. Images from paper: "Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding" (click image for sources) – Related to this are: [[topological atomic precision]] & [[termination control]].]] | + | [[File:Finite Assembly of Three‐Dimensional DNA.jpg|800px|thumb|right|'''First level of self-assembly''' is self folding of the staples strands (short DNA oligomers) to the hexagonal building blocks. Not shown. <br>'''Second level of self-assembly''' is self finding of the hexagonal building blocks. Shown. <br>Here this goes one step further in attempting to make a sandard set of blocks for the second assembly level such that arbitrary larger structures can be built quickly and easily. Custom blocks may be more versatile but are one off solutions for specific desireed geometeries. '''You get individually controllable voxels at the second self-assembly-level too.''' Images from paper: "Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding" (click image for sources) – Related to this are: [[topological atomic precision]] & [[termination control]].]] |
| − | == | + | == Hierarchical selfassembly with [[de-novo proteins]] == |
| + | |||
| + | '''First level of self-assembly''' is self folding of the polypeptide chain. <br> | ||
| + | That might happen right after protein expression. | ||
| + | |||
| + | The big caveat and still present obstacle to overcome here with proteins is absence of [[termination control]]. <br> | ||
| + | {{wikitodo|Add the paper(s) about non-terminating de-novo protein walls.}} <br> | ||
| + | Done't be fooled by the beauty of scale and symmetry of de-novo protein structures that already can't be made. <br> | ||
| + | The difficult part is breaking the symmetry in near arbitrary ways. Like individually controllable voxels. | ||
| + | |||
| + | = Related = | ||
* '''[[Selfassembly level]]''' in [[self assembly]] | * '''[[Selfassembly level]]''' in [[self assembly]] | ||
Revision as of 13:55, 9 March 2024
Up: General concept: Convergent assembly
Hierarchical selfassembly (also convergent selfassembly) is the case when
structures get self-assembled from parts that themselves where previously self-assembled.
This implies that hierarchical selfassembly is a subform of iterative self-assembly.
(Iterative self-assembly also covers repeated additions of parts of the same size.)
Note that hierarchical selfassembly is not exclusive to thermally driven self-assembly.
Hierarchical selfassembly is also applicable to:
Contents
Experimental demonstrations
As of time of last review (2024-03) hierarchical selfassembly has been …
- … impressively demonstrated with 3D structural DNA nanotechnology.
- … demonstrated with de-novo proteins
with the large caveat that of missing termination control.
Note that terminating structures like rings or balls is not a form of termination control as defined in this wiki.
Rotation symmetry is an infinite symmetry (just like translation symmetry in a crystal) just that it covers over itself.
Hierarchical selfassembly of 3D structural DNA nanotechnology (3D-SDN)
Second level of self-assembly is self finding of the hexagonal building blocks. Shown.
Here this goes one step further in attempting to make a sandard set of blocks for the second assembly level such that arbitrary larger structures can be built quickly and easily. Custom blocks may be more versatile but are one off solutions for specific desireed geometeries. You get individually controllable voxels at the second self-assembly-level too. Images from paper: "Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding" (click image for sources) – Related to this are: topological atomic precision & termination control.
Hierarchical selfassembly with de-novo proteins
First level of self-assembly is self folding of the polypeptide chain.
That might happen right after protein expression.
The big caveat and still present obstacle to overcome here with proteins is absence of termination control.
(wiki-TODO: Add the paper(s) about non-terminating de-novo protein walls.)
Done't be fooled by the beauty of scale and symmetry of de-novo protein structures that already can't be made.
The difficult part is breaking the symmetry in near arbitrary ways. Like individually controllable voxels.
Related
- Selfassembly level in self assembly
- complementary is: hierarchical positional assembly here
covered by page convergent assembly & assembly level in positional assembly
