View source for Exponential drop in yield


Synthesizing linear chain molecules (polymers, oldamers) iteratively in vivo the failure likelihood (success rate smaller than factor one) at each addition reaction multiplies. <br>
Given that the success ratios at each steps on average and in general not exceedingly high, <br>
the overall success ratio for an individual chain molecule strand to be synthesized to full lengths as desired with no errors quickly drop down to near zero. <br>
For a large number of identical chains molecules synthesized simultaneously together (as it is the case in such synthetic chemistry) that translates to a low yield and high impurity with incomplete and or faulty chain moleculed.

= Ways to avert this yield-drop in the synthesis of chain molecules (polymers, [[foldamers]]) =

== Near term ==

=== Employing natural synthesis mechanisms ===

* Hijacking the cells machinery (ribosomes & more) for making proteins according to artificial plan 
* There are even chaperone proteins that helping along in post synthesis correct folding
Still expensive experimental stuff: 
* Artificial amino acid tweaks (?)
* Artificial codon tweaks

== Far term ==

[[Piezochemical machanosynthesis]] has low enough error rates for this to not be a problem and even error corrention can be implemented.

= Ways to avert this yield-drop in thermally driven selfassembly of blocks =

Self assembly via [[iterative binding site finding]] suffers from the exact same problem as iterative syntesis of polymers in [[synthetic chemistry]].
The same exponential drop in yield with chain length is prestent.

Self assembly via [[one pot binding site finding]] of 2D or even 3D structures <br>
hugely averts the problem in that assembly can just move around sites of faulty assembly. <br>
For a complete breakdown of all further assembly all paths need to be blocked simultaneously which can get exceedingly unlikely.
[[One pot binding site finding]] comes with other downsides though. Including steric kinetic traps. <br>

Best may be an intermediate approach: [[iterated one pot binding site finding]] <br>
{{todo|Work out the math for the assembly of a stiff rod that is a bundle of several rods where selfassembly can move redundantly arrond faulty assembly sites}}

= Related =

* [[Chemical synthesis]]
* [[Foldamer]]s, [[Spiroligomer]]s, peptidomimentics
* [[Iterated one pot binding site finding]]
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* [[Structural DNA nanotechnology]]
* [[De-novo protein engineering]]