View source for Ribosome like chain assembly

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This is is about assembly methods with nanoscsale devices that
* take in in raw parts (of more or less pre(self)assembled form)
* push out a chain that folds itself up into a bigger product

== Actual ribosomes ==

* Taken in are amino acids linked to much bigger TRNA handles
* Pushed out are protein chains that fold up right away (thermally driven)

Often (always?) membrane proteins assemble right away directly into a target lipid membrane. <br>
Btw: How do the chaperone folding helper proteins come close enough when there is quite a bit of obstruction by the ribosome?

== Blochchain extruding [[Foldamer printer]]s ==

This is about [[foldamer printer]]s that make making parts that are bigger than their own build volume

If the parts of the chain become too big to self-assemble in reasonable timescales [[nonthermal self assembly]] can be used. <br>
It seems this requires the parts to be linked together into a chain. <br>
But the parts are much bigger than simple amino acids here. The parts would be bigger stiff blocks of high geometry. <br>
So this could work more like folding up chain of via hinged linked cuboid (or other highly geometric) blocks.

'''Differences between ribosomes and blockchain extruding [[foldamer printer]]s (on the input side):'''

Ribosomes get their building blocks delivered via a mixed soup of tRNA handles which encode the amino acid they hold. <br>
There is only one binding site which at no time accepts more than one type of amino acid.

Foldamer printers have their building blocks of one type washed in as a pure solution carrying only one type. <br>
And that after a [[site activation]] step where several sites where activated.

{{wikitodo|add illustrative image for that idea}}

== Related ==

* [[Self folding]]: a nanoscale device synthesizing and extruding the foldamer chain is not neccesarily incuded here