Reached milestones in foldamer R&D: Difference between revisions
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* introduction of highly localized compliance (aka hinges) and sliding rails | * introduction of highly localized compliance (aka hinges) and sliding rails | ||
* [[convergent self-assembly|two stage hierarchical self assembly]] (reversible second stage via stiff shape complementarity & salt concentration) | * [[convergent self-assembly|two stage hierarchical self assembly]] (reversible second stage via stiff shape complementarity & salt concentration) | ||
* demonstration of subatomic positional precision (via a hinge mechanism) | * demonstration of subatomic positional precision over a temporal average (via a hinge mechanism) | ||
* multi micron scale atomically precise pegboard structures | * multi micron scale atomically precise pegboard structures | ||
* demonstration of fast electrostatic actuation of structural DNA assemblies | * demonstration of fast electrostatic actuation of structural DNA assemblies | ||
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=== de-novo proteins === | === de-novo proteins === | ||
* high symmetry de-novo protein sheets | * de-novo capsid structures (these lack proper [[noncyclic termination control]] though as rotations without shifts are cyclic coordinates) | ||
* high symmetry de-novo protein sheets (these still lack proper [[noncyclic termination control]] in the fringes) | |||
* ... | * ... | ||
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* pending / outstanding milestone [[Mechanical demultiplexing]] | * pending / outstanding milestone [[Mechanical demultiplexing]] | ||
* [[Incremental path]] | * [[Incremental path]] | ||
[[category:Incremental path]] | |||
Latest revision as of 11:54, 25 June 2026
(wiki-TODO: add technology dependency diagram) (wiki-TODO: reference all the associated papers)
One can identify:
- progress in control of self assembly
- progress in means of actuation of the self assembled structures
Classified by foldamer type
DNA as building material
Highly relevant:
- ending reliance on viral DNA => fully abiotic process
- proof of atomic precision in DNA brick structures (via cryo-TEM-tomography)
- abstraction over low base part symmetry (orthorhombic and hexagonal - slight twist deformation though)
- introduction of highly localized compliance (aka hinges) and sliding rails
- two stage hierarchical self assembly (reversible second stage via stiff shape complementarity & salt concentration)
- demonstration of subatomic positional precision over a temporal average (via a hinge mechanism)
- multi micron scale atomically precise pegboard structures
- demonstration of fast electrostatic actuation of structural DNA assemblies
- ....
Maybe less relevant:
- DNA walkers (unidirectional & bidirectional) -- (wiki-TODO: link related online learning game)
- spacial digital counting (still crude) -- (wiki-TODO: link related talk video)
- stiff DNA triangle cages (note: deltahedrons are stiff polyhedrons)
- DNA tensegrity
de-novo proteins
- de-novo capsid structures (these lack proper noncyclic termination control though as rotations without shifts are cyclic coordinates)
- high symmetry de-novo protein sheets (these still lack proper noncyclic termination control in the fringes)
- ...
Spiroligomers
- ... (TODO: investigate conducted research)
Makroscale base technologies
- DNA oglionucleotide synthesis
- Microfluidics (?)
Related
- Foldamer R&D
- pending / outstanding milestone Mechanical demultiplexing
- Incremental path