Reached milestones in foldamer R&D: Difference between revisions

Latest revision as of 11:54, 25 June 2026

This article is a stub. It needs to be expanded.

(wiki-TODO: add technology dependency diagram) (wiki-TODO: reference all the associated papers)

One can identify:

Highly relevant:

ending reliance on viral DNA => fully abiotic process
proof of atomic precision in DNA brick structures (via cryo-TEM-tomography)
abstraction over low base part symmetry (orthorhombic and hexagonal - slight twist deformation though)
introduction of highly localized compliance (aka hinges) and sliding rails
two stage hierarchical self assembly (reversible second stage via stiff shape complementarity & salt concentration)
demonstration of subatomic positional precision over a temporal average (via a hinge mechanism)
multi micron scale atomically precise pegboard structures
demonstration of fast electrostatic actuation of structural DNA assemblies
....

Maybe less relevant:

DNA walkers (unidirectional & bidirectional) -- (wiki-TODO: link related online learning game)
spacial digital counting (still crude) -- (wiki-TODO: link related talk video)
stiff DNA triangle cages (note: deltahedrons are stiff polyhedrons)
DNA tensegrity

de-novo capsid structures (these lack proper noncyclic termination control though as rotations without shifts are cyclic coordinates)
high symmetry de-novo protein sheets (these still lack proper noncyclic termination control in the fringes)
...

@@ Line 33: / Line 33: @@
 === de-novo proteins ===
-* high symmetry de-novo protein sheets
+* de-novo capsid structures (these lack proper [[noncyclic termination control]] though as rotations without shifts are cyclic coordinates)
+* high symmetry de-novo protein sheets (these still lack proper [[noncyclic termination control]] in the fringes)
 * ...