Tether assisted positional assembly: Difference between revisions

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adding szenario == Modular molecular composite nanosystems for tether assisted positional assembly ==
 
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It seems tether aided assembly is more suitable for assembly than for disassembly or [[site-specific workpiece activation]].
It seems tether aided assembly is more suitable for assembly than for disassembly or [[site-specific workpiece activation]].


== [[Modular molecular composite nanosystems]] for tether assisted positional assembly ==
== [[Modular molecular composite nanosystems]] for tether assisted positional assembly ==


This would be about implementing the weakest possible form of <br>
See: '''[[Mechanosynelf assembly assemblinting system]]s'''
[[mechanosynthesis]] that is not even fully establishing [[machine phase]] yet.  <br>
Just establishing very wide motion corridors. <br>
The [[positional assembly kinematic loop]] can still be very loose and <br>
has not very high demands on positional accuracy yet.
 
'''Here is a slightly concrete crude wild idea example scenario:''' <br>
 
Assuming a [[foldamer]] based scaffold anchored down onto a flat chip surface <br>
(could well be as weak and wobbly as 3D [[structural DNA nanotechnology]]) <br>
with some very simple moving swinging arms. As simple as possible, think "stick on hinge". <br>
allowing to transport pre-selfassembled foldamer bricks by successive handover freely on a 2D grid. <br>
Two orientation of hinges. <br>
Bricks can be structural DNA, or protein, or some other [[foldamers]] or stiffer [[spiroligomers]]). <br>
Later eventually more advanced stuff like [[crystolecules]].
 
Then when several parts are at target sites/pixels <br>
(Perhaps one part for each pixel even? But not at all necessarily so! One can go several rounds for each layer.)  <br>
then an opposing chip is made to approach at the right lateral alignment towards the right distance and  <br>
[[thermally driven self assembly]] does the '''last mile "tether assisted positional assembly"'''.  <br>
 
The opposing chip has a self-assembled build-plate pegboard <br>
or an already partially built up product structure.
 
Operation would look a bit like a resin 3D printer <br>
the target chip plate moving back and forth with <br>
the opposing chip surfaces gradually increasing distance with increasing thickness of the so far built up part. <br>
 
As [[for structural DNA nanotechnology]]: <br>
★ Many micron large slabs of addressable SDN "pegboards" have already been made.  <br>
★ The lack of proper [[termination control]] causing sideways frayed fringes may be acceptable here.  <br>
★ The repeating period of addressing space is also quite big compared to positional capabilities for chips. <br>
 
For this approach to make sense the pre-self-assembled parts need to be the right size. <br>
★ Big enough to be above the [[positional assembly redundancy blockade]] <br>
★ Small enough to be still be under the [[thermal driven selfassembly diffusion speed slowdown blockade]] <br>
 
Initially this would be all about escaping the "upward outeard" scaling corridor
 
'''Clallenges roughly include:''' <br>
★ The self-assembly of the scaffolds pegboard grids for source and target side. <br>
★ Self assembly of the transort mechanisms. As simple as possible. Think "stick on a hinge" that can be made to flap two ways. <br>
★ The pre-self-assembly of foldamer brick structures. <br>
★ Initial feeding with of the source grid with these bricks with known types on known locations. <br>
★ Attaching and detaching bricks on handover and on final deposition to the product. <br>
★ Some very minimalistic nanomechaniocal demultiplexing <br>
… compensating for the large electrodes very likely not being able to address the transport mechanisms individually <br>
★ Accessibility for measurements: The target plate being transparent glass for confocal microscopy maybe? <br>
★ Product extraction, analysis, and eventual use fro some application. <br>
… Cryo EM on single structures usually needs stain and gives much cruder images than using ensembles. <br>
… "Print" several and use tehese as orientation aligned ensemble? <br>
★ no claim to completeness <br>


== Related ==
== Related ==

Latest revision as of 01:08, 6 June 2026

This article defines a novel term (that is hopefully sensibly chosen). The term is introduced to make a concept more concrete and understand its interrelationship with other topics related to atomically precise manufacturing. For details go to the page: Neologism.
The middle one is tether assisted local selfassembly. If there were only one reaction site of only one type in the tethers range it would be just tether assisted assembly. – The scalable vectorgraphic *.svg format of this file is available here.

Top: Spectrum of means of assembly
Up: Tether assisted assembly
Also: Mechanosynelf assembly

Tether assisted positional assembly (or tether aided assembly or weakly guided assembly) is the weakest possible form of mechanosynthesis.
It involves only crude positional guiding to the target (placement) area.
Leaving the part to be placed lots of wiggle-room by holding and guiding it via a tether (flexible chain molecule).

A side-note on naming choice:
There is self assembly involved but it is only "last mile" and
the term tether already implicitly implies the self-assembly aspect plus
there is the other concept of tether assisted selfassembly without any positional assembly involved.
Thus the naming choice of "Tether assisted positional assembly" for the concept presented here.

Positional guidance with "snapping to target"

For reliable reactions there needs to be "snap to target".
That is: An energy energy neds to be dissipated that is >>kT.

Positional assembly atop highly localized (thermally driven) selfassembly

Optionally "last mile self assembly" may still be involved.
That is: Picking out the right reaction site by shape complementarity, but highly localized around the target site.
Encoding of position can be more compact as a smaller address space needs to be covered.

In case of "last mile self assembly" its callable a semi-mechanosynthetic process.
But better stick to "tether aided (local) selfassembly" or
(more general including other things too) weakly guided selfassembly.

Misc

It seems tether aided assembly is more suitable for assembly than for disassembly or site-specific workpiece activation.

Modular molecular composite nanosystems for tether assisted positional assembly

See: Mechanosynelf assembly assemblinting systems

Related