Thermal driven selfassembly diffusion speed slowdown blockade - Revision history

Apm at 14:17, 27 April 2026

2026-04-27T14:17:28Z

← Older revision		Revision as of 16:17, 27 April 2026
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	[[File:APM-EarlyDevelopmentPaths.jpg\|500px\|thumb\|right\|Possible map for the incremental path. The here described blockade appears when just going to the right in the diagram where ist states "too big to diffuse".]]		[[File:APM-EarlyDevelopmentPaths.jpg\|500px\|thumb\|right\|Possible map for the incremental path. The here described blockade appears when just going to the right in the diagram where ist states "too big to diffuse".]]

	With increasingly larger structures/parts/building-blocks diffusion speeds increasingly drop, <br>		With increasingly larger structures/parts/building-blocks the diffusion speeds increasingly drop. <br>
	eventually ~~making~~ [[thermally driven selfassembly]] impractical.		This eventually makes [[thermally driven selfassembly]] impractical. <br>

	So why not just keep adding small parts to big parts then? <br>		So why not just keep adding small parts to big parts then? <br>

Apm at 14:16, 27 April 2026

2026-04-27T14:16:56Z

← Older revision		Revision as of 16:16, 27 April 2026
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	[[File:APM-EarlyDevelopmentPaths.jpg\|500px\|thumb\|right\|Possible map for the incremental path. The here described blockade appears when just going to the right in the diagram where ist states "too big to diffuse".]]		[[File:APM-EarlyDevelopmentPaths.jpg\|500px\|thumb\|right\|Possible map for the incremental path. The here described blockade appears when just going to the right in the diagram where ist states "too big to diffuse".]]

	With increasingly larger structures diffusion speeds increasingly drop, <br>		With increasingly larger structures/parts/building-blocks diffusion speeds increasingly drop, <br>
	eventually making [[thermally driven selfassembly]] impractical.		eventually making [[thermally driven selfassembly]] impractical.

Apm: basic page

2026-04-27T14:16:19Z

basic page

New page

{{site specific term}}
[[File:APM-EarlyDevelopmentPaths.jpg|500px|thumb|right|Possible map for the incremental path. The here described blockade appears when just going to the right in the diagram where ist states "too big to diffuse".]]

With increasingly larger structures diffusion speeds increasingly drop, 
eventually making [[thermally driven selfassembly]] impractical.

So why not just keep adding small parts to big parts then? 
The problem with that idea is that the space of potential binding site gets too large. 
The places that newly added small parts need selectively bind to gets too numerous. 

At some point there is no way around going for some workaround 
which eventually involved [[positional assembly]].

In the diagram the blockade occurs when going only to the right to where it states "too big to diffuse". 

== Complementary blockade ==

Attempting to go to the other side (the left side in the diagram) leads right away 
into to the complementary blockade here on [[APM:About|this wiki]] called "[[positional assembly redundancy blockade]]"
which is present in the context of the [[incremental path]].

This complementary blockade is not present for the [[direct path]] context 
but there the struggle of scaling up ([[convergent assembly]])
is strictly beyond the very hard problem to first go to [[positional assembly]] stage 2 or 3 to the left, 
unless eventually following a [[mixed path]]. 
Thus this diagram makes limited sense for the pure [[direct path]] context. 

== Workarounds ==

* [[hierarchical selfassembly]] making all parts grow in size
* [[tether assisted assisted self assembly]] (also [[mechanosynelf assembly]])
* [[nonthermal self assembly]]
* [[Positional assembly]]

== Bottlenecks assumed to be already taken care of here ==

Note that this is all beyond more basic problems that 
are here assumed to be already optimized so far possible / feasible.

One example in the case of [[structural DNA nanotechnology]]: 
When going to too many free floating parts 
''(oglionucleotide staple strands, aka DNA bricks, acting like vocels filling a roughly cuboid 3D canvas)'' 
then one starts incurring significant slowdown in self-assembly since 
the parts have an increasingly hard time finding their respective (increasingly dilute) binding partners.

One approach to accelerate selfassembly is using a long templating strand.
Incresing effective concentration.
Assing some [[self folding]] to [[self finding]].

Protenins have mostly pure [[self folding]].

== Related ==

* [[Incremental path]]
* [[Positional assembly redundancy blockade]]
* [[Positional assembly kinematic loop]]