System complexity scaling with self-assembly - Revision history

Apm: category:Incremental path

2026-03-29T16:19:09Z

← Older revision		Revision as of 18:19, 29 March 2026
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	<ref name="Zhou2022">Zhou, Yihao & Dong, Jinyi & Zhou, Chao & Wang, Qiangbin. (2022). Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding. Angewandte Chemie International Edition. 61. 10.1002/anie.202116416.</ref>		<ref name="Zhou2022">Zhou, Yihao & Dong, Jinyi & Zhou, Chao & Wang, Qiangbin. (2022). Finite Assembly of Three‐Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding. Angewandte Chemie International Edition. 61. 10.1002/anie.202116416.</ref>
	</references>		</references>

			[[category:Incremental path]]

Apm: /* Related */

2025-05-12T08:20:38Z

← Older revision		Revision as of 10:20, 12 May 2025
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	* [[Squigglesembly]] (possibly not experimentally investigated as of 2024)		* [[Squigglesembly]] (possibly not experimentally investigated as of 2024)
	----		----
	* [[Non-thermal self-assembly]]		* [[Self assembly without dependence on thermal motion\|Non-thermal self-assembly]]
	----		----
	* [[Tether assisted assembly]] mining in some [[positional assembly]] into [[self-assembly]]		* [[Tether assisted assembly]] mining in some [[positional assembly]] into [[self-assembly]]

Apm: /* Tether assisted transport */ fixed link

2024-11-19T19:12:45Z

Tether assisted transport: fixed link

← Older revision		Revision as of 21:12, 19 November 2024
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	– Lower dimensionality of the diffusion degrees of freedom counters slowdown of diffusion from larger part sizes. <br>		– Lower dimensionality of the diffusion degrees of freedom counters slowdown of diffusion from larger part sizes. <br>
	Eventually it might even become possible to add some form of active propulsion. <br>		Eventually it might even become possible to add some form of active propulsion. <br>
	See related page: [[~~Molecular modular~~ composite nanosystem]]s <br>		See related page: [[Modular molecular composite nanosystem]]s <br>

	==== [[Tether assisted assembly]] ====		==== [[Tether assisted assembly]] ====

Apm: /* Tether assisted transport */

2024-11-19T19:12:20Z

Tether assisted transport

← Older revision		Revision as of 21:12, 19 November 2024
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	– Lower dimensionality of the diffusion degrees of freedom counters slowdown of diffusion from larger part sizes. <br>		– Lower dimensionality of the diffusion degrees of freedom counters slowdown of diffusion from larger part sizes. <br>
	Eventually it might even become possible to add some form of active propulsion. <br>		Eventually it might even become possible to add some form of active propulsion. <br>
	See related page: [[Molecular modular composite ~~nanosystems~~]] <br>		See related page: [[Molecular modular composite nanosystem]]s <br>

	==== [[Tether assisted assembly]] ====		==== [[Tether assisted assembly]] ====

Apm: /* Tether assisted assembly */ added section ==== Tether assisted transport ==== and extended ==== Tether assisted assembly ====

2024-11-19T19:11:46Z

Tether assisted assembly: added section ==== Tether assisted transport ==== and extended ==== Tether assisted assembly ====

← Older revision		Revision as of 21:11, 19 November 2024
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	exprimental work on [[algorithmic selfassembly]] in the space of de-novo proteins. <br>		exprimental work on [[algorithmic selfassembly]] in the space of de-novo proteins. <br>

	=== [[Tether assisted assembly]] ===		=== Usage of tethers ===

			==== [[Tether assisted transport]] ====

			Beside addition of small parts to larger ones (as in [[tether assisted assembly]]), <br>
			tethers could also be used to transport larger pre-self-assembled structures in <br>
			an iterative brachiating hand-over kind of way. <br>

			The restriction to a known corridors of movement can be seen as sort of a [[partial machine phase]]. <br>
			Thus it yields similar benefits. It counters two factors of selfassembly slowdown: <br>
			– higher [[effective concentration]] counters the slowdown from thinning of part concentration due to supply depletion <br>
			– Lower dimensionality of the diffusion degrees of freedom counters slowdown of diffusion from larger part sizes. <br>
			Eventually it might even become possible to add some form of active propulsion. <br>
			See related page: [[Molecular modular composite nanosystems]] <br>

			==== [[Tether assisted assembly]] ====

	This kind of <br>		This kind of <br>
	– an easier form of [[self-assembly]] (smaller space to address) mixed with <br>		– an easier form of [[self-assembly]] (smaller space to address) mixed with <br>
	~~–an~~ easier form of [[positional assembly]] (much reduced requirements of positional accuracy) <br>		– an easier form of [[positional assembly]] (much reduced requirements of positional accuracy) <br>
	Very much unexplored territory as of 2024. <br>		Very much unexplored territory as of 2024. <br>

			A challenge here is that positional actuation provided by self-assembled nanosystems is a advanced skill.<br>
			Though the very low precision that is required here may make positional actuation accessible a fair bit earlier <br>
			than cases where more precision (possibly even [[positional atomic precision]]) is necessarily required. <br>

			SPM probe tip might be usable too in case a very small number of structures are to be assembled. <br>

	=== [[Non-thermal self-assembly]] ===		=== [[Non-thermal self-assembly]] ===

Apm: Apm moved page System complexity scaling of self-assembly to System complexity scaling with self-assembly: self-assembly is not what is scaled, scaled is the complexity of the products made WITH it

2024-11-19T12:07:07Z

Apm moved page System complexity scaling of self-assembly to System complexity scaling with self-assembly: self-assembly is not what is scaled, scaled is the complexity of the products made WITH it

← Older revision	Revision as of 14:07, 19 November 2024
(No difference)

Apm: /* External links */ added ReseachGate links with more figures

2024-11-16T12:33:53Z

External links: added ReseachGate links with more figures

← Older revision		Revision as of 14:33, 16 November 2024
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	* https://en.wikipedia.org/wiki/Persistence_length		* https://en.wikipedia.org/wiki/Persistence_length

	=== ~~Papers~~ ===		=== Paper links ===

			* [https://www.nature.com/articles/nature24651 2017 – Gigadalton-scale shape-programmable DNA assemblies (closed access)]
			* [https://www.researchgate.net/publication/321637213_Gigadalton-scale_shape-programmable_DNA_assemblies 2017 – Gigadalton-scale shape-programmable DNA assemblies <br>(via ResearchGate, '''providing free access to more figures''')]
			* Video [https://www.youtube.com/watch?v=UL4zd0nOS5I 2021 – Gigadalton-scale DNA origami nanostructures explained – uploaded by: Logan Thrasher Collins @loganthrashercollins]
			* [https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202116416 2022 – Finite Assembly of Three-Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding (closed access)]
			* [https://www.researchgate.net/publication/358238916_Finite_Assembly_of_Three-Dimensional_DNA_Hierarchical_Nanoarchitectures_through_Orthogonal_and_Directional_Bonding 2022 – Finite Assembly of Three-Dimensional DNA Hierarchical Nanoarchitectures through Orthogonal and Directional Bonding <br>(via ResearchGate, '''providing free access to more figures''')]

			=== Paper references ===

	<references>		<references>

Apm: /* The example of 3D structural DNA nanotechnology (3D-SDN) */ added ResearchGate link

2024-11-16T12:21:28Z

The example of 3D structural DNA nanotechnology (3D-SDN): added ResearchGate link

← Older revision		Revision as of 14:21, 16 November 2024
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	3D [[structural DNA nanotechnology]] has been scaled up to gigadalton scale (hundret thousand atoms) and almost micron scale. <br>		3D [[structural DNA nanotechnology]] has been scaled up to gigadalton scale (hundret thousand atoms) and almost micron scale. <br>
	See <ref name="Wagenbauer2017"/> (not an open access paper unfortunately). <br>		See <ref name="Wagenbauer2017"/> (not an open access paper unfortunately). <br>
			Link with some open access figures: [https://www.researchgate.net/publication/358238916_Finite_Assembly_of_Three-Dimensional_DNA_Hierarchical_Nanoarchitectures_through_Orthogonal_and_Directional_Bonding (Wagenbauer2017) via ResearchGate]

	Granted that this lacks in [[termination control]] to the here in this wiki used definition of it <br>		Granted that this lacks in [[termination control]] to the here in this wiki used definition of it <br>
	where full unbroken spherical symmetry is considered a generalized form of non-termination. <br>		where full unbroken spherical symmetry is considered a generalized form of non-termination. <br>

Apm: /* Known limits / challenges */ added kinetic traps & steric traps & more

2024-11-16T12:17:06Z

Known limits / challenges: added kinetic traps & steric traps & more

← Older revision		Revision as of 14:17, 16 November 2024
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	== Known limits / challenges ==		== Known limits / challenges ==

	* exponential slowdown due to part depletion thin-out		* exponential slowdown of assembly due to part depletion (thin-out)
	* slower diffusion speeds of larger parts		* slower diffusion speeds of larger parts
	* ~~Limits~~ of [[persistence length]]		* limits of [[persistence length]]
			* [[kinetic trap]]s (stuff binding wrongly too strongly and not getting off again)
			* [[steric trap]]s (stuff assembling blocking the path to other stuff that is is not yet fully assembled)
			* Achievable size of sets of orthogonal interfaces
			* …

	== Tricks & workaround methods ==		== Tricks & workaround methods ==

Apm: section reordering

2024-11-16T12:12:51Z

section reordering

@@ Line 6: / Line 6: @@
 much less relevant for quantifying progress than system complexity. <br>
 For details on that see page: [[Quantifying progress by scaling in achievable complexity]] <br>
 == Known limits / challenges ==
@@ Line 104: / Line 86: @@
 Some stuff is more for proteins. <br>
 {{wikitodo|Maybe make this clearer somehow by some repeated analysis pattern.}} <br>
 == Related ==