Sloppy finger problem - Revision history

Apm: category:Incremental path category:Direct path

2026-03-29T16:26:32Z

category:Incremental path category:Direct path

← Older revision		Revision as of 18:26, 29 March 2026
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	* [[Misleading aspects in animations of diamondoid molecular machine elements]]		* [[Misleading aspects in animations of diamondoid molecular machine elements]]
	* [[Gem-gum]]		* [[Gem-gum]]

			[[category:Incremental path]] [[category:Direct path]]

Apm: /* Related */ added two internal links

2024-09-15T05:30:35Z

Related: added two internal links

← Older revision		Revision as of 07:30, 15 September 2024
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	* [[Fat finger problem]]		* [[Fat finger problem]]
	* '''Up: [[The finger problems]]'''		* '''Up: [[The finger problems]]'''
			----
			* [[Misleading aspects in animations of diamondoid molecular machine elements]]
			* [[Gem-gum]]

Apm: /* Related */ Up: The finger problems

2024-02-11T11:17:48Z

Related: Up: The finger problems

← Older revision		Revision as of 13:17, 11 February 2024
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	* '''[[Wobbly finger problem]]'''		* '''[[Wobbly finger problem]]'''
	* [[Fat finger problem]]		* [[Fat finger problem]]
			* '''Up: [[The finger problems]]'''

Apm: /* Related */

2023-08-30T09:04:19Z

← Older revision		Revision as of 11:04, 30 August 2023
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	== Related ==		== Related ==

			* '''[[Wobbly finger problem]]'''
	* [[Fat finger problem]]		* [[Fat finger problem]]

Apm: added links

2021-11-21T21:58:18Z

added links

← Older revision		Revision as of 23:58, 21 November 2021
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			Up: [[The finger problems]]

	== Gemstone based tool-tips ==		== Gemstone based tool-tips ==
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	Integrating stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). <br>		Integrating stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). <br>
	This may combine the best parts of both and solve both problems.		This may combine the best parts of both and solve both problems.

			== Related ==

			* [[Fat finger problem]]

Apm: basic page

2021-11-21T21:55:33Z

basic page

New page

== Gemstone based tool-tips ==

It turned out that the elasticity of the tool-tips can, by choice of sturdy bulky geometry, 
be sufficiently far decreased that thermal vibrations at room temperature 
are not too big to make sufficiently reliable [[piezochemical mechanosynthesis]] impossible. 
Even more so in case active cooling is applied.

== Proteins ==

[[File:FingerStiffnessSpectrum_and_FoldamerTypes_.svg|400px|thumb|right|Floppy fingers enforce fat fingers. Stiff fingers (e.g. red spiroligomers) allow thinner fingers. But such stiffer fingers are still hard to make and spacially arrange (2021).]]

(1) Side-chains on proteins (dark blue shown, light blue indicated) are floppy. 
For side-chains to assume a certain pose (=position and orientation) 
due to their unconstrained sloppiness when standing alone, 
they must be packed tightly between neighboring side-chains.

Since one side-chain cannot hold its pose on its own it is per our definition not a "finger" on it's own. 
Backbones of proteins (black; head on viewed spirals) can be optimized for stiffness by de-novo protein design. 
Enough side-chains on a section of stiff backbone can make a true standalone "finger". 
That is: Changes in one finger do barely influence other fingers as it needs to be for our definition of a "finger". 
But such separable fingers (two red dashed boxes) are way too [[Fat fingers|fat]] to reach down to one and the same moiety on a molecule.

(2) Locally stiff molecules like [[spiroligomers]] (small solid red rectangles) can make 
small independent fingers that have better chances to reach down to one and the same moiety on 
a molecule while still staying independently adjustable. They are independent "fingers". 
But placing these stiffer molecules in a finely adjustable way is likely not easily achievable.
In fact this has not been done as of 2021.

'''A perhaps fruitful approach for a solution:''' 
Integrating stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). 
This may combine the best parts of both and solve both problems.