Separation of concerns - Revision history

Apm: /* In design of artificial advanced productive nanosystems */

2026-10-05T09:46:59Z

In design of artificial advanced productive nanosystems

← Older revision		Revision as of 11:46, 5 October 2026
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	rather than (outdated) ultra compact self replication monolitic[[molecular assemblers]] following the biological cell analogy. <br>		rather than (outdated) ultra compact self replication monolitic[[molecular assemblers]] following the biological cell analogy. <br>

	Both for [[bootstrapping]] ([[~~MMCN~~]]s, [[early diamondoid nanosystem pixel (direct path)]]) <br>		Both for [[bootstrapping]] ([[Modular molecular composite nanosystem]]s, [[early diamondoid nanosystem pixel (direct path)]]) <br>
	and for [[advanced productive nanosystem]]s ([[gemstone metamaterial on chip factory]]). <br>		and for [[advanced productive nanosystem]]s ([[gemstone metamaterial on chip factory]]). <br>

Apm: /* In design of "early" nanosystems / Modular molecular composite nanosystems

2026-10-05T09:45:57Z

In design of "early" nanosystems: * Modular molecular composite nanosystems

← Older revision		Revision as of 11:45, 5 October 2026
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	* [[2D rail-frame based distributed modular pick-place assembly system]]		* [[2D rail-frame based distributed modular pick-place assembly system]]
	* [[Early diamondoid nanosystem pixel (direct path)]]		* [[Early diamondoid nanosystem pixel (direct path)]]
			* [[Modular molecular composite nanosystem]]s

	== In evolution and life ==		== In evolution and life ==

Apm: /* In design of artificial advanced productive nanosystems */ added short conclusionsdiscussion

2026-10-05T09:44:58Z

In design of artificial advanced productive nanosystems: added short conclusionsdiscussion

← Older revision		Revision as of 11:44, 5 October 2026
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	* better testability that is: easier narrowing down of bugs and		* better testability that is: easier narrowing down of bugs and
	* better system comprehesability		* better system comprehesability

			=> Well distributed well debugable systems <br>
			rather than (outdated) ultra compact self replication monolitic[[molecular assemblers]] following the biological cell analogy. <br>

			Both for [[bootstrapping]] ([[MMCN]]s, [[early diamondoid nanosystem pixel (direct path)]]) <br>
			and for [[advanced productive nanosystem]]s ([[gemstone metamaterial on chip factory]]). <br>

	== In design of "early" nanosystems ==		== In design of "early" nanosystems ==

Apm: /* At least three competing purposes for protein side-chains */

2026-10-05T09:37:04Z

At least three competing purposes for protein side-chains

← Older revision		Revision as of 11:37, 5 October 2026
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	* inter protein binding (protein quarternary structure; larger interfaces needed for decently controllable and stiff binding angles)		* inter protein binding (protein quarternary structure; larger interfaces needed for decently controllable and stiff binding angles)
	* outer functionality (binding small molecules and possibly catalyzing reactions between them)		* outer functionality (binding small molecules and possibly catalyzing reactions between them)
	* (allosteric long range motion transmission effects looking beyond stiff proteins as building blocks)		* (allosteric long range motion transmission effects – when looking beyond stiff proteins as building blocks)

	Related: [[Orthogonal set of protein binding interfaces]]		Related: [[Orthogonal set of protein binding interfaces]]

Apm: /* In protein folding */ added section === At least three competing purposes for protein side-chains === & === Holistic behavior on single side chain changes ===

2026-10-05T09:36:38Z

In protein folding: added section === At least three competing purposes for protein side-chains === & === Holistic behavior on single side chain changes ===

← Older revision		Revision as of 11:36, 5 October 2026
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	== In protein folding ==		== In protein folding ==

			=== At least three competing purposes for protein side-chains ===

			* internal cohesion (hydrophobic side-chains in aqueous solution tend to nestle inside; lack of that gives intrinsically disordered proteins or worse)
			* inter protein binding (protein quarternary structure; larger interfaces needed for decently controllable and stiff binding angles)
			* outer functionality (binding small molecules and possibly catalyzing reactions between them)
			* (allosteric long range motion transmission effects looking beyond stiff proteins as building blocks)

			Related: [[Orthogonal set of protein binding interfaces]]

			=== Holistic behavior on single side chain changes ===

	Changing one side-chain on a protein to change a specific function <br>		Changing one side-chain on a protein to change a specific function <br>
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	That is why stiff predictable folding protein motifs are of especial interest. <br>		That is why stiff predictable folding protein motifs are of especial interest. <br>
	~~Prootein~~ that are rather insensitive to local changes. <br>		Protein that are rather insensitive to local changes. <br>
	See: [[De-novo protein engineering]]		See: [[De-novo protein engineering]]

			Related: [[Fat finger problem]]

	== In design of artificial [[advanced productive nanosystem]]s ==		== In design of artificial [[advanced productive nanosystem]]s ==

Apm: /* In design of "early" nanosystems */

2026-07-26T13:15:16Z

In design of "early" nanosystems

← Older revision		Revision as of 15:15, 26 July 2026
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	== In design of "early" nanosystems ==		== In design of "early" nanosystems ==

	The ~~stong~~ separation ~~ino onré~~ task only units in the cases of: <br>		The strong separation into one-task-only units in the cases of: <br>
	* [[2D rail-frame based distributed modular pick-place assembly system]]		* [[2D rail-frame based distributed modular pick-place assembly system]]
	* [[Early diamondoid nanosystem pixel (direct path)]]		* [[Early diamondoid nanosystem pixel (direct path)]]

Apm: In design of "early" nanosystems

2026-07-26T13:14:49Z

In design of "early" nanosystems

← Older revision		Revision as of 15:14, 26 July 2026
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	* better testability that is: easier narrowing down of bugs and		* better testability that is: easier narrowing down of bugs and
	* better system comprehesability		* better system comprehesability

			== In design of "early" nanosystems ==

			The stong separation ino onré task only units in the cases of: <br>
			* [[2D rail-frame based distributed modular pick-place assembly system]]
			* [[Early diamondoid nanosystem pixel (direct path)]]

	== In evolution and life ==		== In evolution and life ==

Apm: Category: Incremental path

2026-03-29T18:02:20Z

Category: Incremental path

← Older revision		Revision as of 20:02, 29 March 2026
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	* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info ~ i.e. more concrete as of 2024-03])		* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info ~ i.e. more concrete as of 2024-03])
	* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])		* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])

			[[Category: Incremental path]]

Apm: /* Generally in research and engineering */

2024-03-17T11:49:31Z

Generally in research and engineering

← Older revision		Revision as of 13:49, 17 March 2024
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	Clear separation-of-concerns and changing just one parameter at a time is no longer a viable option. <br>		Clear separation-of-concerns and changing just one parameter at a time is no longer a viable option. <br>
	Then there are available statistical methods that can help. <br>		Then there are available statistical methods that can help. <br>
	* Youtube video: [https://www.youtube.com/watch?v=5oULEuOoRd0 Test Multiple Variables at Once to Optimize Anything – by NightHawkInLight]		* Youtube video: [https://www.youtube.com/watch?v=5oULEuOoRd0 Test Multiple Variables at Once to Optimize Anything – by NightHawkInLight] (Taguchi arrays)
	* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info ~ i.e. more concrete as of 2024-03])		* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info ~ i.e. more concrete as of 2024-03])
	* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])		* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])

Apm: /* Generally in research and engineering */

2024-03-17T11:48:14Z

Generally in research and engineering

← Older revision		Revision as of 13:48, 17 March 2024
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	Then there are available statistical methods that can help. <br>		Then there are available statistical methods that can help. <br>
	* Youtube video: [https://www.youtube.com/watch?v=5oULEuOoRd0 Test Multiple Variables at Once to Optimize Anything – by NightHawkInLight]		* Youtube video: [https://www.youtube.com/watch?v=5oULEuOoRd0 Test Multiple Variables at Once to Optimize Anything – by NightHawkInLight]
	* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info])		* Wikipedia: [https://en.wikipedia.org/wiki/Taguchi_methods Taguchi_methods] ([https://de.wikipedia.org/wiki/Taguchi-Methode German page with other info ~ i.e. more concrete as of 2024-03])
	* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])		* Wikipedia: [https://en.wikipedia.org/wiki/Design_of_experiments Design of experiments (DOE)] ([https://de.wikipedia.org/wiki/Statistische_Versuchsplanung German page "statistical experiment-planning"])

Separation of concerns - Revision history

Apm: /* In design of artificial advanced productive nanosystems */

Apm: /* In design of "early" nanosystems */ * Modular molecular composite nanosystems

Apm: /* In design of artificial advanced productive nanosystems */ added short conclusionsdiscussion

Apm: /* At least three competing purposes for protein side-chains */

Apm: /* In protein folding */ added section === At least three competing purposes for protein side-chains === & === Holistic behavior on single side chain changes ===

Apm: /* In design of "early" nanosystems */

Apm: In design of "early" nanosystems

Apm: Category: Incremental path

Apm: /* Generally in research and engineering */

Apm: /* Generally in research and engineering */

Apm: /* In design of "early" nanosystems / Modular molecular composite nanosystems