Present-forward development - Revision history

Apm: /* Related */ Experimental work relevant for or targeted at APMnT

2026-09-24T12:31:43Z

← Older revision		Revision as of 14:31, 24 September 2026
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	* [[Funding contexts and their degree of viability]]		* [[Funding contexts and their degree of viability]]
	* [[Present-forward Future-backward overlap]]		* [[Present-forward Future-backward overlap]]
			----
			* '''[[Experimental work relevant for or targeted at APMnT]]'''

Apm: /* Related / Present-forward Future-backward overlap

2023-07-21T16:41:44Z

← Older revision		Revision as of 18:41, 21 July 2023
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	* R&D in constructive/additive use of [[Scanning probe microscopy]]		* R&D in constructive/additive use of [[Scanning probe microscopy]]
	* [[Funding contexts and their degree of viability]]		* [[Funding contexts and their degree of viability]]
			* [[Present-forward Future-backward overlap]]

Apm: crude addition - needs improvement - or split-off to own page

2021-03-15T23:25:54Z

crude addition - needs improvement - or split-off to own page

@@ Line 174: / Line 174: @@
 {{wikitodo|add details here}}
 = Related =
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 * [[Foldamer R&D]]
 * R&D in constructive/additive use of [[Scanning probe microscopy]]

Apm: changed headline hierarchy - prep for adding more top level topics

2021-03-15T09:43:47Z

changed headline hierarchy - prep for adding more top level topics

← Older revision		Revision as of 11:43, 15 March 2021
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	* Integrating the learned mechanosynthetic capabilities into the learned foldamer capabilities (likely in solvent first)		* Integrating the learned mechanosynthetic capabilities into the learned foldamer capabilities (likely in solvent first)

			= Areas =

	= Foldamer Technology =		== Foldamer Technology ==

	'''Needed is:'''		'''Needed is:'''
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	Or one of the stiffer technologies unexpectedly starts scaling better.		Or one of the stiffer technologies unexpectedly starts scaling better.

	== Low stiffness foldamer technologies ==		=== Low stiffness foldamer technologies ===

	Of main interest here may be the Structural DNA nanotechnologies (SDN). <br>		Of main interest here may be the Structural DNA nanotechnologies (SDN). <br>
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	{{wikitodo\|add a sketch of that idea here}} <br>		{{wikitodo\|add a sketch of that idea here}} <br>

	== Mid stiffness foldamer technologies ==		=== Mid stiffness foldamer technologies ===

	'''Of main interest here may be de-novo protein engineering.''' <br>		'''Of main interest here may be de-novo protein engineering.''' <br>
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	* their higher folding predictability		* their higher folding predictability

	== High stiffness foldamer technologies ==		=== High stiffness foldamer technologies ===

	'''One promising candidate here may be Spiroligomers.''' <br>		'''One promising candidate here may be Spiroligomers.''' <br>
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	(Note that this is somewhat speculative. The author has never worked with Spiroligomers.)		(Note that this is somewhat speculative. The author has never worked with Spiroligomers.)

	= Fat fingers =		== Fat fingers ==

	Here's a motivational/economic problem:		Here's a motivational/economic problem:
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	* … is a problem for near term applications - elaboration follows		* … is a problem for near term applications - elaboration follows

	== spacing caused by pushing for modularization ==		=== spacing caused by pushing for modularization ===

	Take a typical proteins(enzymes) active site (the pocket where molecules get bound and manipulated).		Take a typical proteins(enzymes) active site (the pocket where molecules get bound and manipulated).
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	* …		* …

	== Effects of very big spacing through foldamer in foldamer insets (pushing for stiffness) ==		=== Effects of very big spacing through foldamer in foldamer insets (pushing for stiffness) ===

	Really far apart spacing like in the case of the proposed foldamer in foldamer insert also comes with another effect.		Really far apart spacing like in the case of the proposed foldamer in foldamer insert also comes with another effect.
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	See [[Mechanochemistry]]		See [[Mechanochemistry]]

	== Loss of combinatorial power while gains are not yet harvest-able ==		=== Loss of combinatorial power while gains are not yet harvest-able ===

	The capability of easily trying a huge number of random mutations is a powerful tool for many of today's medical applications.		The capability of easily trying a huge number of random mutations is a powerful tool for many of today's medical applications.
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	The fingers that are now spaced apart much more become unable to collaborate in huge number on the same local section of a small molecule. So the power for near term application in this regard is lost.		The fingers that are now spaced apart much more become unable to collaborate in huge number on the same local section of a small molecule. So the power for near term application in this regard is lost.

	= Experimentally accessible very early forms of force applying mechanosynthesis =		== Experimentally accessible very early forms of force applying mechanosynthesis ==

	This has been done on silicon.		This has been done on silicon.
	{{wikitodo\|add details here}}		{{wikitodo\|add details here}}



	= Related =		= Related =

Apm: removed the papers section again since moved to page Foldamer R&D

2021-03-13T11:35:49Z

removed the papers section again since moved to page Foldamer R&D

@@ Line 172: / Line 172: @@
 This has been done on silicon.
 {{wikitodo|add details here}}
 = Related =

Apm: added related section

2021-03-13T11:29:12Z

added related section

← Older revision		Revision as of 13:29, 13 March 2021
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	* Weblink (walled access): http://science.sciencemag.org/content/348/6241/1365.figures-only		* Weblink (walled access): http://science.sciencemag.org/content/348/6241/1365.figures-only
	* Open: https://cryoem.ucla.edu/uploads/image/pdfs/2015_gonen.pdf		* Open: https://cryoem.ucla.edu/uploads/image/pdfs/2015_gonen.pdf

			= Related =

			* [[Foldamer R&D]]
			* R&D in constructive/additive use of [[Scanning probe microscopy]]

Apm: added list of relevant seeming papers

2021-03-13T11:26:28Z

added list of relevant seeming papers

@@ Line 167: / Line 167: @@
 This in turn requires spreading out the fingers.
 The fingers that are now spaced apart much more become unable to collaborate in huge number on the same local section of a small molecule. So the power for near term application in this regard is lost.
 = Experimentally accessible very early forms of force applying mechanosynthesis =
@@ Line 173: / Line 172: @@
 This has been done on silicon.
 {{wikitodo|add details here}}

Apm: added link to: page Structural DNA nanotechnology

2021-03-12T16:59:33Z

added link to: page Structural DNA nanotechnology

← Older revision		Revision as of 18:59, 12 March 2021
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	Complementary: [[Future-backward development]]		Complementary: [[Future-backward development]]

	Here counting to "~~present~~-forward development" will be everything that is already investigatable by		Here counting to "future-forward development" will be everything that is already investigatable by
	experimental means that are accessible today (more or less widely/costly).		experimental means that are accessible today (more or less widely/costly).

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	Of main interest here may be the Structural DNA nanotechnologies (SDN). <br>		Of main interest here may be the Structural DNA nanotechnologies (SDN). <br>
	Especially the DNA-brick kind of SDN. That is: Cuboid blocks from many short DNA oligimer staples.<br>		Especially the DNA-brick kind of SDN. That is: Cuboid blocks from many short DNA oligimer staples.<br>
			Main page: [[Structural DNA nanotechnology]]


	'''Main limitations are:'''		'''Main limitations are:'''

Apm: fixed error: future-forward ==> present-forward

2021-03-12T16:44:24Z

fixed error: future-forward ==> present-forward

← Older revision		Revision as of 18:44, 12 March 2021
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	Complementary: [[Future-backward development]]		Complementary: [[Future-backward development]]

	Here counting to "~~future~~-forward development" will be everything that is already investigatable by		Here counting to "present-forward development" will be everything that is already investigatable by
	experimental means that are accessible today (more or less widely/costly).		experimental means that are accessible today (more or less widely/costly).

Apm: added linkt to: Future-backward development

2021-03-12T15:49:42Z

added linkt to: Future-backward development

← Older revision		Revision as of 17:49, 12 March 2021
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	~~{{stub}}~~		Up: [[Bridging the gaps]] <br>
			Complementary: [[Future-backward development]]
	[[Bridging the gaps]]

	Here counting to "future-forward development" will be everything that is already investigatable by		Here counting to "future-forward development" will be everything that is already investigatable by