<?xml version="1.0"?>
<feed xmlns="http://www.w3.org/2005/Atom" xml:lang="en">
	<id>https://apm.bplaced.net/w/index.php?action=history&amp;feed=atom&amp;title=Learning_from_enzymes</id>
	<title>Learning from enzymes - Revision history</title>
	<link rel="self" type="application/atom+xml" href="https://apm.bplaced.net/w/index.php?action=history&amp;feed=atom&amp;title=Learning_from_enzymes"/>
	<link rel="alternate" type="text/html" href="https://apm.bplaced.net/w/index.php?title=Learning_from_enzymes&amp;action=history"/>
	<updated>2026-04-20T17:19:53Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
	<generator>MediaWiki 1.43.0</generator>
	<entry>
		<id>https://apm.bplaced.net/w/index.php?title=Learning_from_enzymes&amp;diff=9630&amp;oldid=prev</id>
		<title>Apm: improved formatting of the intro</title>
		<link rel="alternate" type="text/html" href="https://apm.bplaced.net/w/index.php?title=Learning_from_enzymes&amp;diff=9630&amp;oldid=prev"/>
		<updated>2021-05-30T14:05:19Z</updated>

		<summary type="html">&lt;p&gt;improved formatting of the intro&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
				&lt;tr class=&quot;diff-title&quot; lang=&quot;en&quot;&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 16:05, 30 May 2021&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot;&gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{stub}}&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;{{stub}}&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&#039;&#039;&#039;What we do not want to copy:&#039;&#039;&#039;&amp;lt;br&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;For [[piezochemical mechanosynthesis]] we do not want to recreate the complex folded background framework of proteins. &amp;lt;br&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;For [[piezochemical mechanosynthesis]] we do not want to recreate the complex folded background framework of proteins. &amp;lt;br&amp;gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-side-deleted&quot;&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&#039;&#039;&#039;What we want to learn from:&#039;&#039;&#039;&amp;lt;br&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;We mostly want too look at and learn from the local geometry right around the reaction site.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;We mostly want too look at and learn from the local geometry right around the reaction site.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;−&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;A question is in how far the optimal trajectories differ with the big advantage of [[piezochemical mechanosynthesis]]&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot; data-marker=&quot;+&quot;&gt;&lt;/td&gt;&lt;td style=&quot;color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;A question is in how far the optimal trajectories differ with the big advantage of [[piezochemical mechanosynthesis]] &lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&amp;lt;br&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;to be capable of applying huge forces and torques onto the chemical bonds.&lt;/div&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;to be capable of applying huge forces and torques onto the chemical bonds.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;td class=&quot;diff-marker&quot;&gt;&lt;/td&gt;&lt;td style=&quot;background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;br&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Apm</name></author>
	</entry>
	<entry>
		<id>https://apm.bplaced.net/w/index.php?title=Learning_from_enzymes&amp;diff=9628&amp;oldid=prev</id>
		<title>Apm: basic page – added section on the fat finger problem – should add that info over there too I guess</title>
		<link rel="alternate" type="text/html" href="https://apm.bplaced.net/w/index.php?title=Learning_from_enzymes&amp;diff=9628&amp;oldid=prev"/>
		<updated>2021-05-30T14:02:01Z</updated>

		<summary type="html">&lt;p&gt;basic page – added section on the fat finger problem – should add that info over there too I guess&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;{{stub}}&lt;br /&gt;
&lt;br /&gt;
For [[piezochemical mechanosynthesis]] we do not want to recreate the complex folded background framework of proteins. &amp;lt;br&amp;gt;&lt;br /&gt;
We mostly want too look at and learn from the local geometry right around the reaction site.&lt;br /&gt;
&lt;br /&gt;
A question is in how far the optimal trajectories differ with the big advantage of [[piezochemical mechanosynthesis]]&lt;br /&gt;
to be capable of applying huge forces and torques onto the chemical bonds.&lt;br /&gt;
&lt;br /&gt;
== Regarding the [[fat finger problem]] ==&lt;br /&gt;
&lt;br /&gt;
Most of the floppy &amp;quot;fingers&amp;quot; (side chains) of enzymes are actually just there to recognize and capture the molecule(s) to be transformed. &amp;lt;br&amp;gt;&lt;br /&gt;
Correct position is encoded in shape. This is not necessary for [[machine phase systems]].&lt;br /&gt;
&lt;br /&gt;
Generally:&lt;br /&gt;
* Getting eight &amp;quot;fingers&amp;quot; together is quite easy in case of resource molecule preparation&lt;br /&gt;
* Getting four &amp;quot;fingers&amp;quot; together is quite easy above a flat surface&lt;br /&gt;
&lt;br /&gt;
In a streaming assembly line like setup (which subtracts one degree of freedom):&lt;br /&gt;
* Getting three &amp;quot;fingers&amp;quot; together is quite easy in case of resource molecule preparation&lt;br /&gt;
* Getting two &amp;quot;fingers&amp;quot; together is quite easy above a flat surface&lt;br /&gt;
&lt;br /&gt;
Ideal targets for [[piezochemical mechanosynthesis]] are &lt;br /&gt;
* small point like resource molecules and &lt;br /&gt;
* volume filling gemstone like [[crystolecules]].&lt;br /&gt;
Both [[stiffness|stiff]]. &amp;lt;br&amp;gt;&lt;br /&gt;
But even chain like molecules can be handled when constrained sufficiently by stretching sections of them out. &amp;lt;br&amp;gt;&lt;br /&gt;
Mechanosynthesis of diamond actually requires synthesizing short chain appendages to form the loops of the diamond crystal structure. &amp;lt;br&amp;gt;&lt;br /&gt;
This is outlined in meticulous detail in the [[tooltip cycle paper]].&lt;br /&gt;
&lt;br /&gt;
== Related ==&lt;br /&gt;
&lt;br /&gt;
[[Mechanosynthetic resource molecule splitting]]:&lt;br /&gt;
* [[Mechanosynthetic carbon dioxide molecule splitting]]&lt;br /&gt;
* [[Mechanosynthetic water splitting]]&lt;br /&gt;
* [[Mechanosynthetic dinitrogen splitting]]&lt;/div&gt;</summary>
		<author><name>Apm</name></author>
	</entry>
</feed>