Fat finger problem - Revision history

Apm: category:Incremental path category:Direct path

2026-03-29T16:25:20Z

category:Incremental path category:Direct path

← Older revision		Revision as of 18:25, 29 March 2026
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	* '''[[Positional assembly kinematic loop]]'''		* '''[[Positional assembly kinematic loop]]'''
	* [[Positional assembly redundancy blockade]] … an other issue encountered in the same region of the [[progress diagram]]		* [[Positional assembly redundancy blockade]] … an other issue encountered in the same region of the [[progress diagram]]

			[[category:Incremental path]]
			[[category:Direct path]]

Apm: /* Related / addded link to page '''Positional assembly kinematic loop'''

2025-05-06T11:51:27Z

Related: addded link to page * '''Positional assembly kinematic loop'''

← Older revision		Revision as of 13:51, 6 May 2025
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	* '''[[Combining advantages of different selfassembly technologies]]'''		* '''[[Combining advantages of different selfassembly technologies]]'''
	----		----
			* '''[[Positional assembly kinematic loop]]'''
	* [[Positional assembly redundancy blockade]] … an other issue encountered in the same region of the [[progress diagram]]		* [[Positional assembly redundancy blockade]] … an other issue encountered in the same region of the [[progress diagram]]

Apm: /* Related */ added link to page Positional assembly redundancy blockade

2025-05-06T11:49:15Z

Related: added link to page Positional assembly redundancy blockade

← Older revision		Revision as of 13:49, 6 May 2025
Line 76:		Line 76:
	----		----
	* '''[[Combining advantages of different selfassembly technologies]]'''		* '''[[Combining advantages of different selfassembly technologies]]'''
			----
			* [[Positional assembly redundancy blockade]] … an other issue encountered in the same region of the [[progress diagram]]

Apm at 11:27, 27 June 2023

2023-06-27T11:27:45Z

← Older revision		Revision as of 13:27, 27 June 2023
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			'''Up: [[The finger problems]]'''
	[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]		[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]

Apm: /* Related / '''Combining advantages of different selfassembly technologies'''

2023-06-27T11:26:59Z

← Older revision		Revision as of 13:26, 27 June 2023
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	* [[Sticky finger problem]]		* [[Sticky finger problem]]
	* ([[Sloppy finger problem]])		* ([[Sloppy finger problem]])
	* [[The finger problems]]		* '''Up: [[The finger problems]]'''
	* [[Learning from enzymes]]		* [[Learning from enzymes]]
	* [[Mechanosynthesis]]		* [[Mechanosynthesis]]
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	----		----
	* [[Spiroligomers]]		* [[Spiroligomers]]
			----
			* '''[[Combining advantages of different selfassembly technologies]]'''

Apm: /* Related / added Spiroligomers

2023-02-04T09:58:11Z

Related: added * Spiroligomers

← Older revision		Revision as of 11:58, 4 February 2023
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	* [[Separation of concerns]]		* [[Separation of concerns]]
	* [[History]]		* [[History]]
			----
			* [[Spiroligomers]]

Apm: /* Related / (Sloppy finger problem)

2021-11-21T21:38:05Z

Related: * (Sloppy finger problem)

← Older revision		Revision as of 23:38, 21 November 2021
Line 65:		Line 65:

	* [[Sticky finger problem]]		* [[Sticky finger problem]]
			* ([[Sloppy finger problem]])
	* [[The finger problems]]		* [[The finger problems]]
	* [[Learning from enzymes]]		* [[Learning from enzymes]]

Apm: /* Related / added Separation of concerns

2021-11-21T21:36:02Z

Related: added * Separation of concerns

← Older revision		Revision as of 23:36, 21 November 2021
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	* [[Learning from enzymes]]		* [[Learning from enzymes]]
	* [[Mechanosynthesis]]		* [[Mechanosynthesis]]
			* [[Separation of concerns]]
	* [[History]]		* [[History]]

Apm: black

2021-10-09T15:21:42Z

black

← Older revision		Revision as of 17:21, 9 October 2021
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	[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]		[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]

	[[File:FingerStiffnessSpectrum_and_FoldamerTypes_.svg\|400px\|thumb\|right\|(1) Sidechains on proteins (dark blue shown, light blue indicated) are floppy. For sidechains to assume a certain pose (=position and orientation) they must be packed tightly between neighboring side-chains. Since one side-chain cannot hold its pose on its own it is per our definition not a "finger" on it's own. Backbones of proteins can be optimized for stiffness by de-novo protein design. Enough side-chains on a section of stiff backbone can make a true standalone "finger". That is: Changes in one finger do barely influence other fingers as it needs to be for our definition of a "finger". But such separable fingers (two red dashed boxes) are way too fat to reach down to one and the same moiety on a molecule. – (2) Locally stiff molecules like [[spiroligomers]] (small solid red rectangles) can make small independent fingers that have better chances to reach down to one and the same moiety on a molecule while still staying independently adjustable. They are independent "fingers". But placing these stiffer molecules in a finely adjustable way is likely not easily achievable. In fact this has not been done as of 2021. – '''Approach for a solution:''' Integrateing stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). This may combine the best parts of both and solve both problems.]]		[[File:FingerStiffnessSpectrum_and_FoldamerTypes_.svg\|400px\|thumb\|right\|(1) Sidechains on proteins (dark blue shown, light blue indicated) are floppy. For sidechains to assume a certain pose (=position and orientation) they must be packed tightly between neighboring side-chains. Since one side-chain cannot hold its pose on its own it is per our definition not a "finger" on it's own. Backbones of proteins (black; head on viewed sirals) can be optimized for stiffness by de-novo protein design. Enough side-chains on a section of stiff backbone can make a true standalone "finger". That is: Changes in one finger do barely influence other fingers as it needs to be for our definition of a "finger". But such separable fingers (two red dashed boxes) are way too fat to reach down to one and the same moiety on a molecule. – (2) Locally stiff molecules like [[spiroligomers]] (small solid red rectangles) can make small independent fingers that have better chances to reach down to one and the same moiety on a molecule while still staying independently adjustable. They are independent "fingers". But placing these stiffer molecules in a finely adjustable way is likely not easily achievable. In fact this has not been done as of 2021. – '''Approach for a solution:''' Integrateing stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). This may combine the best parts of both and solve both problems.]]

	Because the "fingers" of a manipulator mechanism ([[stiffness\|not "arms" those lack stiffness]]) must themselves be made out of atoms, they have a certain irreducible size. Thus one might worry that there just isn't enough room in the nanometer-size reaction region to accommodate the number of "fingers" necessary for performing the desired atom by atom reactions.		Because the "fingers" of a manipulator mechanism ([[stiffness\|not "arms" those lack stiffness]]) must themselves be made out of atoms, they have a certain irreducible size. Thus one might worry that there just isn't enough room in the nanometer-size reaction region to accommodate the number of "fingers" necessary for performing the desired atom by atom reactions.

Apm: /* "Fingers fatness" in earlier productive nanosystems */

2021-10-09T14:11:05Z

"Fingers fatness" in earlier productive nanosystems

← Older revision		Revision as of 16:11, 9 October 2021
Line 18:		Line 18:

	By designing [[foldamer]]s (proteins or others) with de-novo methodology and adding stiffer molecules (like e.g. [[spiroligomers]]), <br>		By designing [[foldamer]]s (proteins or others) with de-novo methodology and adding stiffer molecules (like e.g. [[spiroligomers]]), <br>
	it might be possible to make proper stiff ~~idependently~~ changeable "fingers" much more compact and pointy in than natural examples (biomineralization). <br>		it might be possible to make proper stiff independently changeable "fingers" much more compact and pointy in than natural examples (biomineralization). <br>
	As of 2017 still very little work has been done in this area. <br>		As of 2017 still very little work has been done in this area. <br>
	{{Todo\|Research in "[[in solution piezochemical mechanosynthesis]]" is urgently needed.}}		{{Todo\|Research in "[[in solution piezochemical mechanosynthesis]]" is urgently needed.}}

← Older revision		Revision as of 17:21, 9 October 2021
Line 1:		Line 1:
	[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]		[[File:MinToolset_FatFingersNoProblem.png\|400px\|thumb\|right\|With advanced gemstone like materials (like e.g. diamondoids including diamond) reaching down towards small moieties from multiple sides simultaneously is possible without loosing too much stiffness. Source: [[Tooltip cycle paper]].]]

	[[File:FingerStiffnessSpectrum_and_FoldamerTypes_.svg\|400px\|thumb\|right\|(1) Sidechains on proteins (dark blue shown, light blue indicated) are floppy. For sidechains to assume a certain pose (=position and orientation) they must be packed tightly between neighboring side-chains. Since one side-chain cannot hold its pose on its own it is per our definition not a "finger" on it's own. Backbones of proteins can be optimized for stiffness by de-novo protein design. Enough side-chains on a section of stiff backbone can make a true standalone "finger". That is: Changes in one finger do barely influence other fingers as it needs to be for our definition of a "finger". But such separable fingers (two red dashed boxes) are way too fat to reach down to one and the same moiety on a molecule. – (2) Locally stiff molecules like [[spiroligomers]] (small solid red rectangles) can make small independent fingers that have better chances to reach down to one and the same moiety on a molecule while still staying independently adjustable. They are independent "fingers". But placing these stiffer molecules in a finely adjustable way is likely not easily achievable. In fact this has not been done as of 2021. – '''Approach for a solution:''' Integrateing stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). This may combine the best parts of both and solve both problems.]]		[[File:FingerStiffnessSpectrum_and_FoldamerTypes_.svg\|400px\|thumb\|right\|(1) Sidechains on proteins (dark blue shown, light blue indicated) are floppy. For sidechains to assume a certain pose (=position and orientation) they must be packed tightly between neighboring side-chains. Since one side-chain cannot hold its pose on its own it is per our definition not a "finger" on it's own. Backbones of proteins (black; head on viewed sirals) can be optimized for stiffness by de-novo protein design. Enough side-chains on a section of stiff backbone can make a true standalone "finger". That is: Changes in one finger do barely influence other fingers as it needs to be for our definition of a "finger". But such separable fingers (two red dashed boxes) are way too fat to reach down to one and the same moiety on a molecule. – (2) Locally stiff molecules like [[spiroligomers]] (small solid red rectangles) can make small independent fingers that have better chances to reach down to one and the same moiety on a molecule while still staying independently adjustable. They are independent "fingers". But placing these stiffer molecules in a finely adjustable way is likely not easily achievable. In fact this has not been done as of 2021. – '''Approach for a solution:''' Integrateing stiffer less scalable spiroligomers (2) in less stiff but more scalable proteins (1). This may combine the best parts of both and solve both problems.]]

	Because the "fingers" of a manipulator mechanism ([[stiffness\|not "arms" those lack stiffness]]) must themselves be made out of atoms, they have a certain irreducible size. Thus one might worry that there just isn't enough room in the nanometer-size reaction region to accommodate the number of "fingers" necessary for performing the desired atom by atom reactions.		Because the "fingers" of a manipulator mechanism ([[stiffness\|not "arms" those lack stiffness]]) must themselves be made out of atoms, they have a certain irreducible size. Thus one might worry that there just isn't enough room in the nanometer-size reaction region to accommodate the number of "fingers" necessary for performing the desired atom by atom reactions.

Fat finger problem - Revision history

Apm: category:Incremental path category:Direct path

Apm: /* Related */ addded link to page * '''Positional assembly kinematic loop'''

Apm: /* Related */ added link to page Positional assembly redundancy blockade

Apm at 11:27, 27 June 2023

Apm: /* Related */ * '''Combining advantages of different selfassembly technologies'''

Apm: /* Related */ added * Spiroligomers

Apm: /* Related */ * (Sloppy finger problem)