Convergent self assembly - Revision history

Apm at 16:12, 29 March 2026

2026-03-29T16:12:14Z

← Older revision		Revision as of 18:12, 29 March 2026
Line 54:		Line 54:
	* [[Convergent assembly]]		* [[Convergent assembly]]
	* [[Assembly levels]]		* [[Assembly levels]]

			[[category:Incremental path]]

Apm: added wikitodo

2021-03-28T08:30:05Z

added wikitodo

← Older revision		Revision as of 10:30, 28 March 2021
Line 6:		Line 6:
	Specifically this was demonstrated with the DNA brick approach.		Specifically this was demonstrated with the DNA brick approach.

	{{wikitodo\|add reference links to the relevant papers}}		{{wikitodo\|add reference links to the relevant papers}} <br>
			{{wikitodo\|add a sketch of the process}}

	== First assembly level ==		== First assembly level ==

Apm: some corrections and cleanup

2021-03-28T08:28:17Z

some corrections and cleanup

← Older revision		Revision as of 10:28, 28 March 2021
Line 2:		Line 2:
	= Experimental example demonstrations =		= Experimental example demonstrations =

	As of before 2020 ~~This~~ has already been experimentally demonstrated in [[structural DNA ~~nanotachnology~~]] (SDN). <br>		As of before 2020 convergent self assembly (or convergent thermally driven assembly) <br>
			has already been experimentally demonstrated in [[structural DNA nanotechnology]] (SDN). <br>
	Specifically this was demonstrated with the DNA brick approach.		Specifically this was demonstrated with the DNA brick approach.

Apm: basic version of the page

2021-03-28T08:26:50Z

basic version of the page

New page

= Experimental example demonstrations =

As of before 2020 This has already been experimentally demonstrated in [[structural DNA nanotachnology]] (SDN). 
Specifically this was demonstrated with the DNA brick approach.

{{wikitodo|add reference links to the relevant papers}}

== First assembly level ==

In the first assembly step the right set of "DNA bricks" (which are short pieces of floppy singe stranded DNA aka DNA oligomers) are 
mixed together and thermally annealed to self assemble to bigger somewhat stiff and squarish blocks.

== Second assembly level ==

In the second assembly level these some bigger blocks with complementary shapes where made to self assemble
to even bigger multi block structures by means of salt concentration changed.

= Limitations =

== SDN stiffness and environment limitations ==

The stiffness of SDN structures just barely is sufficient to hold them in somewhat squarish shapes. 
Minor issue: There is a slight natural twist to the bigger squarish blocks. 
This is all performed in solution. 
Given the low stiffness and [[high charges on DNA]] it's seems quite likely that 
drying these structures out could make them shrivel up, deform and maybe break in some way. 
{{todo|investigate this}}.

== de-novo protein alternatives ==

Something in some way similar has not yet been demonstrated with more stiff proteins. 
Thinkable would be:
* A direct analogy with short peptide chains taking the place of of protein oligomers
* Using wolde folded de-novo proteins as bricks

The latter suffers from the situation that in de-novo protein systems it is hard 
to get bigger sets of [[orthogonal sets of interfaces]].

The former suffers from the situation that proteins are 
by evolution not as specifically tailored to pairing up as DNA is.

== other foldamers or polymers ==

TODO ...

== Related ==

* [[Structural DNA nanotechnology]]
----
In more advanced technology levels with positional control
* [[Convergent assembly]]
* [[Assembly levels]]