Circumsembly - Revision history

Apm: category:Incremental path

2026-03-29T16:07:59Z

← Older revision		Revision as of 18:07, 29 March 2026
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	----		----
	* [[Persistence length]]		* [[Persistence length]]

			[[category:Incremental path]]

Apm: /* Benefits of circumsembly */ added note on stiffness

2024-11-18T19:23:43Z

Benefits of circumsembly: added note on stiffness

← Older revision		Revision as of 21:23, 18 November 2024
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	This is likely easy for n=2 analytically. <br>		This is likely easy for n=2 analytically. <br>
	For bigger n this might be easiest answered with a simulation.<br>		For bigger n this might be easiest answered with a simulation.<br>
			----
			Multiple paths to the same point is larger than zero stiffness per path <br>
			can contribute to overall shape based structural stiffness. <br>
			One may hit the limits of [[persistence length]] later.

	== Related ==		== Related ==

Apm: /* Related / added link to page Persistence length

2024-11-18T19:21:16Z

Related: added link to page * Persistence length

← Older revision		Revision as of 21:21, 18 November 2024
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	* [[de-novo proteins]]		* [[de-novo proteins]]
	* [[steric traps]]		* [[steric traps]]
			----
			* [[Persistence length]]

Apm: link to SDN

2023-06-27T09:33:03Z

link to SDN

← Older revision		Revision as of 11:33, 27 June 2023
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	[[File:Circumsembly.png\|600px\|thumb\|right\|A semi-conceptual illustration visualizing fault tolerance in selfassembly		[[File:Circumsembly.png\|600px\|thumb\|right\|A semi-conceptual illustration visualizing fault tolerance in selfassembly
	(at first and second assembly level) enabled by provision of parallel pathways for		(at first and second assembly level) enabled by provision of parallel pathways for
	the completion of still missing areas of self-assembly. – 3D voxel block structural DNA nanotechnology used as inspiring example. ]]		the completion of still missing areas of self-assembly. – 3D voxel block [[structural DNA nanotechnology]] used as inspiring example. ]]

	'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>		'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>

Apm: added image with description

2023-06-27T09:32:11Z

added image with description

← Older revision		Revision as of 11:32, 27 June 2023
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	{{site specific term}}		{{site specific term}}
			[[File:Circumsembly.png\|600px\|thumb\|right\|A semi-conceptual illustration visualizing fault tolerance in selfassembly
			(at first and second assembly level) enabled by provision of parallel pathways for
			the completion of still missing areas of self-assembly. – 3D voxel block structural DNA nanotechnology used as inspiring example. ]]

	'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>		'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>
	different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br>		different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br>

Apm: /* Related */ steric traps

2022-05-16T14:55:29Z

Related: steric traps

← Older revision		Revision as of 16:55, 16 May 2022
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	== Related ==		== Related ==

	* [[~~Termination~~ control]]		* [[termination control]]
	* [[~~Squigglesembly~~]]		* [[squigglesembly]]
	* [[de-novo proteins]]		* [[de-novo proteins]]
			* [[steric traps]]

Apm at 15:41, 13 May 2022

2022-05-13T15:41:18Z

← Older revision		Revision as of 17:41, 13 May 2022
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	Minus the few irreversible assembly errors which can be tolerated in a good design.<br>		Minus the few irreversible assembly errors which can be tolerated in a good design.<br>
	{{wikitodo\|add a sketch}}		{{wikitodo\|add a sketch}}

			(Choice of name: "circum" from circumventing assembly errors.)

	== Relation to yield in the synthesis of chain molecules ==		== Relation to yield in the synthesis of chain molecules ==

Apm at 15:39, 13 May 2022

2022-05-13T15:39:08Z

← Older revision		Revision as of 17:39, 13 May 2022
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	if up to (n-1) paths between A & B are blocked by irreversible assembly errors, self-assembly can still proceed from A all the way to B.<br>		if up to (n-1) paths between A & B are blocked by irreversible assembly errors, self-assembly can still proceed from A all the way to B.<br>
	In practice much less than (n-1) paths should ever be blocked and the wole product assembled.		In practice much less than (n-1) paths should ever be blocked and the wole product assembled.
	Minus the few irreversible assembly errors which can be tolerated in a good design.		Minus the few irreversible assembly errors which can be tolerated in a good design.<br>
			{{wikitodo\|add a sketch}}

	== Relation to yield in the synthesis of chain molecules ==		== Relation to yield in the synthesis of chain molecules ==
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	But a stiff rod made from several parallel sub-strands can circumvent irreversible errors.		But a stiff rod made from several parallel sub-strands can circumvent irreversible errors.

	== Prerequisites ==		== Prerequisites for circumsembly ==

	* selfassembly at multiple spots simultaneously		* selfassembly at multiple spots simultaneously
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	* sufficient stiffness of selfassemblies such that the same spot can be reached via multiple (at least two) pathways		* sufficient stiffness of selfassemblies such that the same spot can be reached via multiple (at least two) pathways

	== Benefits ==		== Benefits of circumsembly ==

	* A much reduced dropoff in yield of product. <br>Especially for 2d and 3D structures where the number of paths for circumvention grows quadratically/cubically respectively.		* A much reduced dropoff in yield of product. <br>Especially for 2d and 3D structures where the number of paths for circumvention grows quadratically/cubically respectively.

Apm at 15:37, 13 May 2022

2022-05-13T15:37:45Z

← Older revision		Revision as of 17:37, 13 May 2022
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	{{site specific term}}		{{site specific term}}

	'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>		'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>
	different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br>		different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br>

Apm: Improved on intro

2022-05-13T15:37:36Z

Improved on intro

← Older revision		Revision as of 17:37, 13 May 2022
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	{{site specific term}}		{{site specific term}}

	~~Artificial~~ synthesis of chain molecules by iterative addition of monomers to the reactive end <br>		'''Circumsembly''' (or redundant access self-assembly) is selfassembly where <br>
			different parts A and B of the product-to-self-assemble are reachable by n (n being at least two) possible pathways, such that<br>
			if up to (n-1) paths between A & B are blocked by irreversible assembly errors, self-assembly can still proceed from A all the way to B.<br>
			In practice much less than (n-1) paths should ever be blocked and the wole product assembled.
			Minus the few irreversible assembly errors which can be tolerated in a good design.

			== Relation to yield in the synthesis of chain molecules ==

			artificial synthesis of chain molecules by iterative addition of monomers to the reactive end <br>
	suffers from exponential/geometric drop-off in yield.<br>		suffers from exponential/geometric drop-off in yield.<br>
	With every added monomer a probability smaller one of failure is multiplied. <br>		With every added monomer a probability smaller one of failure is multiplied. <br>