Reached milestones in foldamer R&D

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(wiki-TODO: add technology dependency diagram) (wiki-TODO: reference all the associated papers)

One can identify:

  • progress in control of self assembly
  • progress in means of actuation of the self assembled structures

Classified by foldamer type

DNA as building material

Highly relevant:

  • ending reliance on viral DNA => fully abiotic process
  • proof of atomic precision in DNA brick structures (via cryo-TEM-tomography)
  • abstraction over low base part symmetry (orthorhombic and hexagonal - slight twist deformation though)
  • introduction of highly localized compliance (aka hinges) and sliding rails
  • two stage hierarchical self assembly (reversible second stage via stiff shape complementarity & salt concentration)
  • demonstration of subatomic positional precision (via a hinge mechanism)
  • multi micron scale atomically precise pegboard structures
  • demonstration of fast electrostatic actuation of structural DNA assemblies
  • ....

Maybe less relevant:

  • DNA walkers (unidirectional & bidirectional) -- (wiki-TODO: link related online learning game)
  • spacial digital counting (still crude) -- (wiki-TODO: link related talk video)
  • stiff DNA triangle cages (note: deltahedrons are stiff polyhedrons)
  • DNA tensegrity

de-novo proteins

  • high symmetry de-novo protein sheets
  • ...


  • ... (TODO: investigate conducted research)

Makroscale base technologies

  • DNA oglionucleotide synthesis
  • Microfluidics (?)