Iterative self-assembly

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This article is a stub. It needs to be expanded.

Iterative self assembly is letting things fully self-assemble before mixing in the next kind(s) of building blocks.

  • All reactive sites that shall not be filled with one of the parts in the next wash-in should
    be fully saturated before proceeding with the next step.
  • There needs to be a way for sufficiently thorough wash-outs and wash-ins such that
    the desired products keep staying in the reaction volume. E.g. attachment to large surfaces provided by some sort of larger scale micro-beads.

Iterative assembly can provide a basis for
circumventing the limitations of de-novo proteins in termination control.

Sub-classification

  • added parts are roughly of same size – no external pre-selfassembly steps happening
  • hierarchical selfassembly – combining products of preceding in parallel executed one-pot self-assembly processes
    – this modifies above's constraints a bit (wiki-TODO: discuss that)

Related

The complement to iterative self-assembly is one-pot self-assembly.
Iterative self-assembly can also be a sequence of one-pot self-assembly steps.