Foldamer R&D

• structural DNA nanotechnology
• de-novo protein engineering
• peptidomimetics like peptoids (& beta-peptides)
• spiroligomers

Related

• Incremental path
• Reached milestones in foldamer R&D
• Self folding
• covalent cross interlinking (increasing stiffness)
• POPs (persistant organic pollutants) -- See: "Soil pollutants"
• Microfluidics

External links

• Wikipedia: Foldamer
• Wikipedia: De_novo_protein_structure_prediction
• Wikipedia: PeptidomimeticPeptoidBeta-peptide

Video: "Clasp: Common Lisp using LLVM and C++ for Molecular Metaprogramming" [1]
Published on Jun 15, 2015 – Google Tech Talk – June 9, 2015 – Presented by Christian Schafmeister.

This video also brings up topics like:

• The importance of stiffness – double linked backbones prevent rotations making resulting structures much easier to desing and more predictable
• Iterative design of early forms of Kaehler brackets
  optimization of a stiff backbone to get functional groups as close as possible to a fixed predefined configuration (that may have been stolen from a natural protein)
• General software issues – programming language limitations, the dreaded interface problem,
  "deforresting" unnecessary computer algebra reevaluations (a problem also showing up in volumetric 3D modelling aka distance field based 3D modelling; Design levels),
  the need for derivation towers (scalar,vector,tensor) (automatic derivation - links to Conal Elliotts work)
• Going deep down the rabbit-hole to reach a far term target (in an highly non-obvious way for outsiders).
  Sidenote: That's exactly where natural evolution has severe limitations.
• Invention (and market introduction) of covalent protein crosslinking technology
• Bootstrapping of the synthesis of the fundamental spiroligomer building blocks
• The "indestructibility" of spiroligomers raise the issue of the waste problem with POPs (persistent organic pollutants) -- See: Recycling
• The suspected lignin pileup in the Carboniferous epoch of earths history.
• The talk doesn't look beyond towards gemstone based systems as far term goal. Partially brownian technology path?